Results 101 to 110 of about 5,085,322 (244)

Higher vitamin B12 from mid‐ to late life is related to slower rates of cognitive decline

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Evidence is needed to evaluate whether low vitamin B12 from mid‐ to late life, either alone or in the presence of elevated folate, is associated with cognitive decline. METHODS Participants from the Framingham Heart Study without baseline dementia who had ≥ 2 measures of a three‐component vitamin B12 indicator (3cB12) and ...
Francesca R. Marino, Gail Rogers, Joshua W. Miller, Jacob Selhub, Jesse Mez, Paul K. Crane, Shubhabrata Mukherjee, Andrew J. Saykin, Timothy J. Hohman, Emily H. Trittschuh, Rhoda Au, Paul F. Jacques, Phillip H. Hwang   +12 more
wiley   +1 more source

Not So Rare: Errors of Metabolism during the Neonatal Period

, 2003
During the neonatal period, the diagnosis of an error of metabolism (EM) was once thought to portend a poor prognosis or lethality. Over the past two decades, the prognosis of many EMs has changed.
Banta-Wright, Sandra, Steiner, Robert D.
core   +1 more source

بررسی سطح سرمی ويتامين B12، Folate و هموسيستئين در سالمندان سالم تهرانی [PDF]

, 2009
زمينه و هدف: از آنجائيکه جذب کوبالامين اغلب در سالمندان کاهش می‌يابد، کمبود ويتامين B12 يکی از مشکلات شايع در اين افراد است. تحقيقات اخير نشان می‌دهند که ميزان ناکافی ويتامين B12 ممکن است خطر ابتلا به بيماری‌های آترواسکلروتيک و نورودژنراتيو را افزايش دهد.
خدابنده‌لو, نیلوفر, فروغان, مهشید, قلعه‌بندی, میرفرهاد, نجومی, مرضیه, وکيلی, مسعود   +4 more
core  

Cloning and expression of the Propionibacterium shermanii methylmalonyl-CoA epimerase gene in Escherichia coli : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1994
Genomic DNA was isolated from Propionibacterium shermanii (52W). A 454 bp DNA fragment coding for the methylmalonyl-CoA epimerase (EC 5.1.99.1, subsequently referred to as epimerase) was amplified from genomic DNA by the polymerase chain reaction using ...
Saafi, 'Etuate Lui
core  

Inborn errors of metabolism: a clinical overview [PDF]

, 1999
CONTEXT: Inborn errors of metabolism cause hereditary metabolic diseases (HMD) and classically they result from the lack of activity of one or more specific enzymes or defects in the transportation of proteins.
Martins, Ana Maria
core   +4 more sources

Biochemical Pattern of Methylmalonyl-CoA Epimerase Deficiency Identified in Newborn Screening: A Case Report

International Journal of Neonatal Screening
Methylmalonyl-CoA epimerase enzyme (MCEE) is responsible for catalyzing the isomeric conversion between D- and L-methylmalonyl-CoA, an intermediate along the conversion of propionyl-CoA to succinyl-CoA.
Evelina Maines, Roberto Franceschi, Francesca Rivieri, Giovanni Piccoli, Björn Schulte, Jessica Hoffmann, Andrea Bordugo, Giulia Rodella, Francesca Teofoli, Monica Vincenzi, Massimo Soffiati, Marta Camilot   +11 more
doaj   +1 more source

Novel c.2216T > C (p.I739T) Mutation in Exon 13 and c.1481T > A (p.L494X) Mutation in Exon 8 of MUT Gene in a Female with Methylmalonic Acidemia [PDF]

, 2013
We report herein a 1.5-year-old girl with methylmalonic acidemia (MMA) in whom two missense mutations were found: a novel I739T mutation located in exon 13 and the L494X mutation in exon 8. The results of organic acid test showed a pronounced increase in
George Imataka, Go Tajima, Hideo Yamanouchi, Osamu Arisaka, Osamu Sakamoto, Shigemi Yoshihara, Yuki Omura-Hasegawa   +6 more
core   +1 more source

Maleic Acid – but Not Structurally Related Methylmalonic Acid – Interrupts Energy Metabolism by Impaired Calcium Homeostasis

PLoS ONE, 2015
Maleic acid (MA) has been shown to induce Fanconi syndrome via disturbance of renal energy homeostasis, though the underlying pathomechanism is still under debate.
A. Tuncel, T. Ruppert, Bei-Tzu Wang, J. Okun, S. Kölker, M. Morath, S. Sauer   +6 more
semanticscholar   +1 more source

Ion suppression, reduced long-term robustness and leakage current of the spray voltage during the ionization of trichloroacetic acid; a case study with a methylmalonic acid assay

, 2023
Arjen M. Punt, Kim C. M. van der Elst, Alwin D. R. Huitema, Eef G.W.M. Lentjes   +3 more
openalex   +1 more source

Evaluation of peripheral and autonomic nervous systems dysfunctions in patients with Parkinson’s disease

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Peripheral neuropathy (PN) is increasingly recognized in Parkinson’s disease (PD). This study aimed to evaluate peripheral nerve and autonomic nervous system dysfunction in PD.
Osama A. Ragab, Ehab S. Mohamed, Mahmoud H. Nassar   +2 more
doaj   +1 more source