Results 111 to 120 of about 2,508,935 (158)
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Serum methylmalonic acid in uraemia
Scandinavian Journal of Clinical and Laboratory Investigation, 1992During a 3 month period we measured serum methylmalonic acid concentrations monthly in 37 patients, all on chronic haemodialysis because of end-stage kidney disease. Concentrations of methylmalonic acid in serum were above the upper reference limit in 36 of the 37 subjects.
L, Moelby, K, Rasmussen, H H, Rasmussen
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Pediatrics, 1973
Methylmalonate studies have led to some understanding of vitamin B12 metabolism as well as certain inborn errors of metabolism. These, in turn, have served as models of a group of diseases related to acidosis, so that the study of organic aciduria at present is similar to that of amino aciduria 20 years ago.
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Methylmalonate studies have led to some understanding of vitamin B12 metabolism as well as certain inborn errors of metabolism. These, in turn, have served as models of a group of diseases related to acidosis, so that the study of organic aciduria at present is similar to that of amino aciduria 20 years ago.
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Methylmalonic Acid in Dialysis Patients
Hemodialysis International, 2003Propionyl-CoA is a common product of metabolism of essential AA (Val, Thr, Leu, Ile), fatty acids and cholesterol and is further metabolised enzymatically to methyl-malonyl CoA, which is further isomerised to succinyl CoA. Because of the common cofactor (cobalamin) methylmalonic acid (Mma) can serve as an early marker of functional cobalamin deficiency.
L. Svoboda +3 more
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Methylmalonic acid in aging and disease
Trends in Endocrinology & MetabolismMetabolic byproducts have conventionally been disregarded as waste products without functions. In this opinion article, we bring to light the multifaceted role of methylmalonic acid (MMA), a byproduct of the propionate metabolism pathway mostly commonly known as a clinical biomarker of vitamin B12 deficiency.
Joanne Tejero +2 more
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The assay of methylmalonic acid in urine
Clinica Chimica Acta, 1972Abstract The assay of methylmalonic acid in urine by modifications of the method of Giorgio and Plaut 5 , together with the use of a three wavelength correction is described. This revised procedure made possible the detection of small increases in the output of methylmalonic acid in vitamin B 12 deficiency which could not be estimated by the ...
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Colorimetric Method for Determination of Urinary Methylmalonic Acid
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1979The colorimetric method for the determination of methylmalonic acid by coupling with diazotised p-nitroaniline has been re-examined. Extraction of the diazotised product into amyl alcohol and tetra-methyl ammonium hydroxide considerably increases its stability and sensitivity and reduces background absorbance.
A, Westwood, W, Taylor, G, Davies
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A rapid method for the analysis of urinary methylmalonic acid
Clinica Chimica Acta, 1972Abstract A method for the determination of urinary methylmalonic acid, applicable on a routine clinical basis, is described. The method is based on the isolation of a mono-tooligo-carboxylic acid fraction from urine by a series of ether extractions and the subsequent gas Chromatographie analysis of these acids as their trimethylsilyl esters and ...
B F, Gibbs +4 more
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Serum cobalamin and methylmalonic acid in Alzheimer dementia
Acta Neurologica Scandinavica, 2009The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite accumulating early in cobalamin deficiency.
M O, Kristensen +4 more
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METABOLIC PRECURSORS OF METHYLMALONIC ACID IN VITAMIN-B12 DEFICIENCY
The Lancet, 1967Abstract Valine, isoleucine and sodium propionate have been investigated as precursors of urinary methylmalonic acid in patients with vitamin B12 deficiency. Valine was administered to fifteen patients with vitamin B12 deficiency and provoked an increased excretion of methylmalonic acid in all cases. The same dose of valine had no effect on excretion
D, Gompertz, J H, Jones, J P, Knowles
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Comparison of automated and manual methods of estimation of methylmalonic acid
Analytical Biochemistry, 1975Abstract An automated method for estimation of methylmalonic acid in urine is described that compares well with results obtained by a manual method. The temperature at which color is developed can be set anywhere between ambient and 90°C without loss of linearity over a certain range of concentrations. The higher temperatures have greater sensitivity
S M, Oace, S C, Chen
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