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The isolation of methylmalonic acid from rat urine [PDF]
Biochemical Journal, 1936 E, Boyland, A A, Levi
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Effect of vitamin B12 derivatives on urinary excretion of methylmalonic acid in liver diseases
1. Twenty.one patients with liver diseases were studied for their urinary mehylmalonic acid excretion after a valine load by means of an improved thin layer chromatography. 2.
Ueda, Masatoshi, Taketa, Kazuhisa
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Corrigendum: The Value of Liver Transplantation for Methylmalonic Acidemia
Frontiers in Pediatrics, 2020 Yi-Zhou Jiang +4 more
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Methylmalonic acid — an endogenous toxin?
Cellular and Molecular Life Sciences, 2005Methylmalonic acid was previously considered as major neurotoxin in methylmalonic acidurias. In contrast, recent studies support the notion that other metabolites deriving from propionyl-coenzyme A, inducing synergistic inhibition of mitochondrial energy metabolism, are more important than methylmalonic acid to understand the neuropathogenesis of this ...
Stefan Koelker
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Pediatric Transplantation, 2010
Methylmalonic acidemia with complete mutase deficiency (mut(0) type) is an inborn error of metabolism with high mortality and morbidity. LT has been suggested to be a solution to this disease, but elevation of urinary and blood MMA was still observed after LT.
P W, Chen +6 more
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Methylmalonic acidemia with complete mutase deficiency (mut(0) type) is an inborn error of metabolism with high mortality and morbidity. LT has been suggested to be a solution to this disease, but elevation of urinary and blood MMA was still observed after LT.
P W, Chen +6 more
exaly +3 more sources
Ascorbic acid and α-tocopherol attenuate methylmalonic acid-induced convulsions
NeuroReport, 1999 The effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically injected with alpha-tocopherol (40 mg kg(-1), i.p.), melatonin (5 mg kg(-1), i.p.) or vehicle for 7 days.
Fighera, M. R. +7 more
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Diagnostic Performances of Urinary Methylmalonic Acid/Creatinine Ratio in Vitamin B12 Deficiency
Journal of Clinical Medicine, 2020 Sole measurement of plasma vitamin B12 is no longer enough to identify vitamin B12 (B12) deficiency. When plasma vitamin B12 is in the low-normal range, especially between 201 and 350 ng/L, B12 deficiency should be assessed by measurements of plasma ...
Geoffrey Urbanski +2 more
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Methylmalonic Acid Excretion Studies
British Journal of Haematology, 1973Summary. Oral valine and isoleucine were equally effective in producing an increased urinary excretion of methylmalonic acid (MMA) in vitamin B12 deficiency but oral MMA itself, methionine and leucine were unsatisfactory.MMA excretion was increased in 16 out of 23 patients with vitamin B12 deficiency after valine and/or isoleucine loading but remained
I, Chanarin +3 more
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