Results 11 to 20 of about 5,085,322 (244)

Serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or other acute enteropathies [PDF]

Journal of Veterinary Internal Medicine, 2023
Background Low serum cobalamin concentrations have been associated with ileal malabsorption in dogs with chronic enteropathy. Increased serum methylmalonic acid (MMA) concentrations indicate cobalamin deficiency on a cellular level.
Michael Hung, Justin Heinz, Jӧrg M. Steiner, Jan Suchodolski, Jonathan Lidbury   +4 more
doaj   +4 more sources

Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study [PDF]

BMC Medicine, 2020
Methylmalonic acid (MMA) is best known for its use as a functional marker of vitamin B12 deficiency. However, MMA concentrations not only depend on adequate vitamin B12 status, but also relate to renal function and endogenous production of propionic acid.
I. Riphagen, Isidor Minović, D. Groothof, A. Post, Manfred L. Eggersdorfer, Jenny E. Kootstra-Ros, M. D. de Borst, G. Navis, F. Muskiet, I. Kema, M. Heiner-Fokkema, Stephan J. L. Bakker   +11 more
semanticscholar   +2 more sources

Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke [PDF]

Romanian Journal of Laboratory Medicine, 2018
Introduction: Sitosterolemia, defined as phytosterolemia, is a rare autosomal recessive disease characterized by elevated blood sterol levels. Our aim was to investigate serum plant sterols, methylmalonic acid, vitamin B12, oxidized-LDL and homocysteine ...
Sivrikaya Abdullah, Ozturk Serefnur, Ekmekci Hakan, Sağlam Aslıhan, Abusoglu Sedat, Unlu Ali   +5 more
doaj   +2 more sources

Diagnostic Performances of Urinary Methylmalonic Acid/Creatinine Ratio in Vitamin B12 Deficiency. [PDF]

J Clin Med, 2020
Sole measurement of plasma vitamin B12 is no longer enough to identify vitamin B12 (B12) deficiency. When plasma vitamin B12 is in the low-normal range, especially between 201 and 350 ng/L, B12 deficiency should be assessed by measurements of plasma ...
Supakul S, Chabrun F, Genebrier S, N'Guyen M, Valarche G, Derieppe A, Villoteau A, Lacombe V, Urbanski G.   +8 more
europepmc   +2 more sources

The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q₁₀ Status and Mitochondrial Function. [PDF]

Int J Mol Sci, 2020
Methylmalonic acidemia is an inborn metabolic disease of propionate catabolism, biochemically characterized by accumulation of methylmalonic acid (MMA) to millimolar concentrations in tissues and body fluids. However, MMA’s role in the pathophysiology of
Proctor EC, Turton N, Boan EJ, Bennett E, Philips S, Heaton RA, Hargreaves IP.   +6 more
europepmc   +2 more sources

Methylmalonic acidemia: Neurodevelopment and neuroimaging

Frontiers in Neuroscience, 2023
Methylmalonic acidemia (MMA) is a genetic disease of abnormal organic acid metabolism, which is one of the important factors affecting the survival rate and quality of life of newborns or infants. Early detection and diagnosis are particularly important.
Tao Chen, Yian Gao, Shengdong Zhang, Yuanyuan Wang, Chaofan Sui, Linfeng Yang   +5 more
doaj   +2 more sources

Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria [PDF]

Molecular Genetics and Metabolism, 2019
Methylmalonic acidemia (MMA) is a propionate pathway disorder caused by dysfunction of the mitochondrial enzyme methylmalonyl-CoA mutase (MMUT). MMUT catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an anaplerotic reaction which feeds into ...
Baumgartner, Matthias R, Chapman, Kimberly A, Cunningham, Gary, Forny, Patrick, Pumbo, Elena, Summar, Marshall L, Wongkittichote, Parith   +6 more
core   +3 more sources

Homocysteine and methylmalonic acid in Phenylketonuria patients [PDF]

Genetics and Molecular Biology
Hyperhomocysteinemia and vitamin B12 deficiency have been reported in patients with phenylketonuria. In this study, total homocysteine (tHcy) and methylmalonic acid (MMA) levels were analyzed in samples from 25 phenylketonuria (PKU) patients. Comparisons
Giovana Regina Weber Hoss, Fernanda Sperb-Ludwig, Tássia Tonon, Soraia Poloni, Sidney Behringer, Henk J. Blom, François Maillot, Ida Vanessa Doederlein Schwartz   +7 more
doaj   +2 more sources

Antioxidant System Disturbances, Bioenergetic Disruption, and Glial Reactivity Induced by Methylmalonic Acid in the Developing Rat Brain [PDF]

Neuroglia
Background: Elevated levels of methylmalonic acid (MMA) are observed in the bodily fluids and tissues of patients with methylmalonic aciduria, a metabolic disorder characterized by manifestations such as vomiting, lethargy, muscle weakness, seizures, and
Cristiano Antonio Dalpizolo, Josyane de Andrade Silveira, Manuela Bianchin Marcuzzo, Vitor Gayger-Dias, Vanessa-Fernanda Da Silva, Camila Vieira Pinheiro, Bruno Pereira dos Santos, Tiago Franco de Oliveira, Carlos-Alberto Gonçalves, Guilhian Leipnitz   +9 more
doaj   +2 more sources

Correlation between toxic organic acid fluctuations and neurodevelopment in patients with methylmalonic acidemia [PDF]

Orphanet Journal of Rare Diseases
Background Methylmalonic acidemia (MMA) is a rare autosomal recessive disorder, that causes multisystem damage by accumulating toxic metabolites. These metabolites, particularly affecting nerve cells, contribute to suboptimal neurodevelopment in MMA ...
I.-Chih Ling, Dau-Ming Niu, Chia-Feng Yang, Cheng-Yu Lee, Sheng-Bin Liang, Yann-Jang Chen   +5 more
doaj   +2 more sources