Results 201 to 210 of about 13,373 (259)

Functional Vitamin B12 Deficiency Represented by Elevated Urine Methylmalonic Acid Levels in Patients with Migraine

, 2008
Osman Metin İpçioğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekelı, Mehmet Güney Şenol   +4 more
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Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis

Yige Liu, Jiaxin Wang, Hengxuan Cai, Zeng Wang, Rongzhe Lu, Xiaoxuan Liu, Mingyang Wang, Wei Wang, Junchen Guo, Guanpeng Ma, Zhenming Zhang, Pengyan Wu, Qin She, Xiaoming Wu, Lili Xiu, Bo Yu, Xueqin Gao, Zhaoying Li, Shanjie Wang, Shaohong Fang   +19 more
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Methylmalonic Acid Excretion Studies

British Journal of Haematology, 1973
Summary. Oral valine and isoleucine were equally effective in producing an increased urinary excretion of methylmalonic acid (MMA) in vitamin B12 deficiency but oral MMA itself, methionine and leucine were unsatisfactory.MMA excretion was increased in 16 out of 23 patients with vitamin B12 deficiency after valine and/or isoleucine loading but remained
I, Chanarin, J M, England, C, Mollin, J, Perry   +3 more
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Serum methylmalonic acid in uraemia

Scandinavian Journal of Clinical and Laboratory Investigation, 1992
During a 3 month period we measured serum methylmalonic acid concentrations monthly in 37 patients, all on chronic haemodialysis because of end-stage kidney disease. Concentrations of methylmalonic acid in serum were above the upper reference limit in 36 of the 37 subjects.
L, Moelby, K, Rasmussen, H H, Rasmussen
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Methylmalonic acid — an endogenous toxin?

Cellular and Molecular Life Sciences, 2005
Methylmalonic acid was previously considered as major neurotoxin in methylmalonic acidurias. In contrast, recent studies support the notion that other metabolites deriving from propionyl-coenzyme A, inducing synergistic inhibition of mitochondrial energy metabolism, are more important than methylmalonic acid to understand the neuropathogenesis of this ...
S, Kölker, J G, Okun
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METHYLMALONIC ACID

Pediatrics, 1973
Methylmalonate studies have led to some understanding of vitamin B12 metabolism as well as certain inborn errors of metabolism. These, in turn, have served as models of a group of diseases related to acidosis, so that the study of organic aciduria at present is similar to that of amino aciduria 20 years ago.
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Methylmalonic Acid in Dialysis Patients

Hemodialysis International, 2003
Propionyl-CoA is a common product of metabolism of essential AA (Val, Thr, Leu, Ile), fatty acids and cholesterol and is further metabolised enzymatically to methyl-malonyl CoA, which is further isomerised to succinyl CoA. Because of the common cofactor (cobalamin) methylmalonic acid (Mma) can serve as an early marker of functional cobalamin deficiency.
L. Svoboda, L. Stráník, J. Hyánek, F. Pehal   +3 more
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Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation

Pediatric Transplantation, 2010
Methylmalonic acidemia with complete mutase deficiency (mut(0) type) is an inborn error of metabolism with high mortality and morbidity. LT has been suggested to be a solution to this disease, but elevation of urinary and blood MMA was still observed after LT.
P W, Chen, W L, Hwu, M C, Ho, N C, Lee, Y H, Chien, Y H, Ni, P H, Lee   +6 more
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Abstract 3175: Methylmalonic acid in TME signaling

Cancer Research, 2022
Abstract The importance of metabolic reprogramming in cancer has been long demonstrated by the association of systemic metabolic changes, such as aging, diet and exercise, with cancer outcomes. These systemic shifts, combined with local metabolic alterations within the tumor microenvironment (TME), can all cooperate to foster an ...
Vivien Low, Zhongchi Li, Ashley Laughney, Wenbing Jin, Noah Dephoure, Valbona Luga, Ethan Earlie, Bobak Parang, Chunjun Guo, Lewis Cantley, John Blenis   +10 more
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Ascorbic acid and α-tocopherol attenuate methylmalonic acid-induced convulsions

NeuroReport, 1999
The effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically injected with alpha-tocopherol (40 mg kg(-1), i.p.), melatonin (5 mg kg(-1), i.p.) or vehicle for 7 days.
Fighera, M. R., Queiroz, C. M., Stracke, M. P., Brauer, MCN, Gonzalez-Rodriguez, L. L., Frussa, R., Wajner, M., Mello, C. F. de   +7 more
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