Results 231 to 240 of about 5,012,650 (270)

METABOLIC PRECURSORS OF METHYLMALONIC ACID IN VITAMIN-B12 DEFICIENCY

The Lancet, 1967
Abstract Valine, isoleucine and sodium propionate have been investigated as precursors of urinary methylmalonic acid in patients with vitamin B12 deficiency. Valine was administered to fifteen patients with vitamin B12 deficiency and provoked an increased excretion of methylmalonic acid in all cases. The same dose of valine had no effect on excretion
J.Hywel Jones, D. Gompertz, J.P. Knowles
openaire   +5 more sources

Plasma methylcitric acid and its correlations with other disease biomarkers: The impact in the follow up of patients with propionic and methylmalonic acidemia

Journal of Inherited Metabolic Disease, 2020
Methylcitric acid (MCA) analysis has been mainly utilized for the diagnosis of propionate disorders or as a second‐tier test in newborn screening, but its utility for patients monitoring still needs to be established.
Evelina Maines, G. Catesini, S. Boenzi, A. Mosca, M. Candusso, L. Dello Strologo, D. Martinelli, A. Maiorana, A. Liguori, G. Olivieri, R. Taurisano, F. Piemonte, C. Rizzo, M. Spada, C. Dionisi-Vici   +14 more
semanticscholar   +1 more source

The assay of methylmalonic acid in urine

Clinica Chimica Acta, 1972
Abstract The assay of methylmalonic acid in urine by modifications of the method of Giorgio and Plaut 5 , together with the use of a three wavelength correction is described. This revised procedure made possible the detection of small increases in the output of methylmalonic acid in vitamin B 12 deficiency which could not be estimated by the ...
openaire   +3 more sources

Kinetics and mechanism for the iodination of methylmalonic acid [PDF]

International Journal of Chemical Kinetics, 1979
AbstractThe reaction\documentclass{article}\pagestyle{empty}\begin{document}$ CH\left({CH_3 } \right)\left({COOH} \right)_2 + I_2 \rightleftharpoons CI(CH_3)\left({COOH} \right)_2 + H^ + + I^ - $\end{document} was followed spectrophotometrically at 353 nm and 470 nm at 25°C under various conditions of pH and methylmalonic acid concentration.
openaire   +2 more sources

Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation

Pediatric Transplantation, 2010
Methylmalonic acidemia with complete mutase deficiency (mut(0) type) is an inborn error of metabolism with high mortality and morbidity. LT has been suggested to be a solution to this disease, but elevation of urinary and blood MMA was still observed after LT.
Yin-Hsiu Chien, Wuh-Liang Hwu, Po-Huang Lee, Ming-Chih Ho, P. W. Chen, Yen-Hsuan Ni, Ni-Chung Lee   +6 more
openaire   +3 more sources

Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

Headache, 2019
Although the exact pathophysiological mechanistic pathways that result in the initiation of migraine attacks remain unclear, there are some proposed mechanisms including neurogenic inflammation, trigeminovascular system activation, vascular dysfunction ...
M. Togha, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Martami, Maryam Seifishahpar   +4 more
semanticscholar   +1 more source

A rapid method for the analysis of urinary methylmalonic acid

Clinica Chimica Acta, 1972
Abstract A method for the determination of urinary methylmalonic acid, applicable on a routine clinical basis, is described. The method is based on the isolation of a mono-tooligo-carboxylic acid fraction from urine by a series of ether extractions and the subsequent gas Chromatographie analysis of these acids as their trimethylsilyl esters and ...
K. Itiaba, Bernard F. Gibbs, J.C. Crawhall, B.A. Cooper, O.A. Mamer   +4 more
openaire   +3 more sources

Serum cobalamin and methylmalonic acid in Alzheimer dementia

Acta Neurologica Scandinavica, 2009
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite accumulating early in cobalamin deficiency.
M. Ø. Kristensen, J. E. J. Christensen, K. Rasmussen, Karen Østergaard, N. C. Gulmann   +4 more
openaire   +2 more sources

N₂O and Urine Methylmalonic Acid in Man

Scandinavian Journal of Haematology, 1983
The excretion of methylmalonic acid was measured and deoxyuridine suppression test (dU‐test) was performed in 5 patients before and after 24 h of ventilation with nitrous oxide. The mean urinary 2‐methylmalonic acid was increased from 90 to 320 μmol/24 h and the dU‐tests became abnormal. These findings indicate that the 2 vitamin B‐12 dependent enzymes,
Leif Freund, Henrik Rask, Anders Schou Olesen, J.Z. Mortensen   +3 more
openaire   +2 more sources

[Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia].

Zhonghua yi xue za zhi, 2013
To analyze the levels of methylmalonic acid and methylcitrate in urine, propionylcarnitine (C3) in plasma and C3/acetylcarnitine (C2) of patients with methylmalonic acidemia (MMA) and explore their applications in the diagnosis of MMA.From December 2003 to March 2012, a total of 162 patients with MMA (MMA group) and 200 healthy children (control group)
Wenjuan Qiu, Lianshu Han, Jun Ye, Sheng-nan Wu, Xiao-yan Li, Hao Xu, Huiwen Zhang, Yu Wang, Xuefan Gu, Xiao-lan Gao   +9 more
openaire   +2 more sources