Results 41 to 50 of about 26,084 (258)

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Prescribing of methylphenidate to children and adolescents in South Africa: A pharmacoepidemiological investigation

South African Family Practice, 2009
Background: Pharmacoepidemiological studies on ADHD are limited in South Africa. The primary aim was to analyse the prescribing of methylphenidate to patients aged 18 years and younger in the private health care sector.
Ilse Truter
doaj   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

Methylphenidate Actively Induces Emergence from General Anesthesia [PDF]

, 2011
Background: Although accumulating evidence suggests that arousal pathways in the brain play important roles in emergence from general anesthesia, the roles of monoaminergic arousal circuits are unclear.
Cimenser, Aylin, Emery N. Brown, Kin F. K. Wong, Wong, Kin F. K., Chemali, Jessica J., Jessica J. Chemali, Brown, Emery N., Ken Solt, Solt, Ken, Cotten, Joseph F., Aylin Cimenser, Joseph F. Cotten   +11 more
core   +1 more source

Reversible cerebral vasoconstriction syndrome in a methylphenidate-treated patient: a case report

BMC Neurology
Background Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by severe headaches, often thunderclap headaches, and a multifocal constriction of the cerebral arteries.
Marie-Noëlle Osmont, Cécile Malrain, Anne-Lise Ruellan, Amine Benchikh, Emmanuelle Herlem, Elisabeth Polard, Lucie-Marie Scailteux   +6 more
doaj   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

The effect of methylphenidate for giggle incontinence in children [PDF]

, 2023
Introduction: Giggle incontinence (GI) is a rare form of urinary incontinence that occurs during or immediately after laughing due to involuntary and complete bladder emptying. Few studies in the literature report that methylphenidate can be effective in
Kristina Nauheimer Thorsteinsson, Mads Arvad, Arvad, Mads, Svendsen, Ann-Kristine Mandoe, Hagstroem, Soeren, Kamperis, Konstantinos, Thorsteinsson, Kristina Nauheimer, Ann-Kristine Mandoe Svendsen, Luise Borch, Borch, Luise, Konstantinos Kamperis, Soeren Hagstroem   +11 more
core   +1 more source

Prevalence of and factors associated with the use of methylphenidate for cognitive enhancement among university students

Einstein (São Paulo), 2019
Objective To estimate the prevalence of and factors associated with the use of methylphenidate for cognitive enhancement among undergraduate students.
Raissa Carolina Fonseca Cândido, Edson Perini, Cristiane Menezes de Pádua, Daniela Rezende Junqueira   +3 more
doaj   +2 more sources

Acute Dose-Related Differential Effects of Methylphenidate on Murine Cystometric Parameters [PDF]

International Neurourology Journal, 2013
Purpose Methylphenidate is the most widely used central nervous system stimulant in patients with attention deficit hyperactivity disorder. However, few studies have assessed its effects on voiding.
Sung Ho Choi, Young Sam Cho, Sung Tae Cho, Tack Lee, Khae Hawn Kim   +4 more
doaj   +1 more source