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Corticosteroid-induced manic and/or psychotic symptoms: a systematic review. [PDF]

open access: yesFront Pharmacol
Gostoli S   +5 more
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Pharmacokinetics of Methylprednisolone, Methylprednisolone Sodium Succinate, and Methylprednisolone Acetate in Dogs

Journal of Pharmaceutical Sciences, 1986
The absolute bioavailability and pharmacokinetic parameters of two methylprednisolone formulations (methylprednisolone sodium succinate and methylprednisolone acetate) were determined in five dogs. Plasma concentrations of methylprednisolone, methylprednisolone sodium succinate, and methylprednisolone acetate were measured by sensitive and specific ...
P.M. Fayolle   +3 more
openaire   +3 more sources

Hydrolysis of methylprednisolone hemisuccinate to methylprednisolone by a nonspecific carboxylesterase

Pharmacological Research Communications, 1980
Summary Enzymatic hydrolysis of methylprednisolone hemisuccinate with a non-specific carboxylesterase from hog liver was examined. The carboxyl-exterase was found to be useful in hydrolyzing methylprednisolone hemisuccinate to methylprednisolone.
T. Oshima, E. Nakajima, K. Hattori
openaire   +3 more sources

Pharmacokinetics of Methylprednisolone Hemisuccinate and Methylprednisolone in Chronic Liver Disease

The Journal of Clinical Pharmacology, 1993
The disposition of methylprednisolone (MP) and its prodrug hemisuccinate (MPHS) was assessed in six middle‐aged patients with chronic liver disease (CLD) and compared with six younger, healthy subjects after a single IV dose of 25.4 mg of MPHS. Blood and urine samples were collected over 12 hours.
Elizabeth A. Ludwig   +3 more
openaire   +3 more sources

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