Results 311 to 320 of about 128,641 (342)
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Methylprednisolone in Status Asthmaticus
Archives of Internal Medicine, 1984To the Editor. —I would like to comment on the recent study by Haskell et al 1 in the JulyArchives. First, this article was welcomed, since there is a paucity of well-designed and executed studies using corticosteroids for treating status asthmaticus. Second, I would disagree slightly with the authors' interpretation of their data.
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Methylprednisolone Acetate In Vasectomy
JAMA: The Journal of the American Medical Association, 1972To the Editor.— Those of your readers who perform vasectomies may be interested in the following observations. Over the past four months I have added methylprednisolone acetate (Depo-Medrol) to the 1% lidocaine hydrochloride (Xylocaine) solution which I routinely inject locally in vasectomies. The results have been quite striking and, in the interest
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International Journal of Pharmaceutics, 2001
The dose-dependency in the pharmacokinetics of a macromolecular prodrug of methylprednisolone (MP), dextran-methylprednisolone succinate (DMP), was investigated in rats. Single doses (MP equivalent) of 2.5, 5.0, 10, 20, and 30 mg/kg of DMP were administered intravenously to rats (n=5/group), and serial blood samples (0-96 h) and spleen and liver ...
Xiaoping Zhang, Reza Mehvar
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The dose-dependency in the pharmacokinetics of a macromolecular prodrug of methylprednisolone (MP), dextran-methylprednisolone succinate (DMP), was investigated in rats. Single doses (MP equivalent) of 2.5, 5.0, 10, 20, and 30 mg/kg of DMP were administered intravenously to rats (n=5/group), and serial blood samples (0-96 h) and spleen and liver ...
Xiaoping Zhang, Reza Mehvar
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Journal of Pharmaceutical and Biomedical Analysis, 2000
A reversed-phase HPLC method is reported for simultaneous quantitation of methylprednisolone (MP), MP succinate (MPS), and endogenous corticosterone (CST) in plasma of rats. Additionally, the 11-keto metabolite of MP (methylprednisone, MPN) is resolved from the other analytes.
Reza Mehvar +2 more
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A reversed-phase HPLC method is reported for simultaneous quantitation of methylprednisolone (MP), MP succinate (MPS), and endogenous corticosterone (CST) in plasma of rats. Additionally, the 11-keto metabolite of MP (methylprednisone, MPN) is resolved from the other analytes.
Reza Mehvar +2 more
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Equine Veterinary Journal, 1986
SummarySynovial fluid and plasma kinetics of methylprednisolone acetate (MPA) and methylprednisolone (MP) after a single intra‐articular administration of MPA at a therapeutic dose (111 mgin toto) was measured in five horses. MPA was detected in synovial fluid for two to six days post injection and MP, which results from synovial MPA hydrolysis, was ...
Michel Alvinerie +2 more
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SummarySynovial fluid and plasma kinetics of methylprednisolone acetate (MPA) and methylprednisolone (MP) after a single intra‐articular administration of MPA at a therapeutic dose (111 mgin toto) was measured in five horses. MPA was detected in synovial fluid for two to six days post injection and MP, which results from synovial MPA hydrolysis, was ...
Michel Alvinerie +2 more
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1990
The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high‐performance liquid chromatography after doses of MPHS of 1.7‐2.4 g.
William J. Jusko +4 more
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The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high‐performance liquid chromatography after doses of MPHS of 1.7‐2.4 g.
William J. Jusko +4 more
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Methylprednisolone-Induced Toxic Hepatitis
Annals of Pharmacotherapy, 2006Objective: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis. Case Summary: A 47-year-old woman was admitted to our clinic with weakness, fatigue, pruritus, and scleral icterus that had developed 10 days prior to presentation.
Ersan Ozaslan +5 more
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Methylprednisolone in Acute Asthma
New England Journal of Medicine, 1986Allan B. Wolfson +7 more
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