Results 11 to 20 of about 371 (109)

Stability of a standardized preparation of methotrexate, cytarabine, and methylprednisolone hemisuccinate for intrathecal use [PDF]

Journal of Oncology Pharmacy Practice, 2022
Introduction Data about the feasibility or stability of drugs prepared for intrathecal administration are scarce, especially concerning the possibility of mixing two or more compounds in the same syringe.
Gianluca Perego, Lucia Vigano, AlbertA Locatelli   +2 more
exaly   +4 more sources

Methylprednisolone-hemisuccinate and its metabolites in serum, urine and bile from two patients with acute graft rejection. [PDF]

Br J Clin Pharmacol, 1995
Methylprednisolone‐hemisuccinate (MPHS), methylprednisolone (MP), 20‐ alpha‐hydroxy‐ (20 alpha HMP) and 20‐beta‐hydroxymethyl‐prednisolone (20 beta HMP) concentrations were measured in serum, urine and bile from two liver transplant recipients who had received 1 g MPHS by a 1 h intravenous infusion for treatment of an acute rejection episode.
Lawson GJ, Chakraborty J, Tredger JM, Baylis EM.   +3 more
europepmc   +5 more sources

A new validated facile HPLC analysis method to determine methylprednisolone including its derivatives and practical application [PDF]

Scientific Reports, 2023
Methylprednisolone sodium succinate (MPSS) is a parenteral water-soluble corticosteroid ester. It gives three peaks methylprednisolone (MP), 17-methylprednisolone hemisuccinate (17-MPHS), and methylprednisolone hemisuccinate (MPHS) that share in the ...
Mostafa F. Al-Hakkani
doaj   +2 more sources

Nano-Drugs Based on Nano Sterically Stabilized Liposomes for the Treatment of Inflammatory Neurodegenerative Diseases. [PDF]

PLoS ONE, 2015
The present study shows the advantages of liposome-based nano-drugs as a novel strategy of delivering active pharmaceutical ingredients for treatment of neurodegenerative diseases that involve neuroinflammation.
Keren Turjeman, Yaelle Bavli, Pablo Kizelsztein, Yaelle Schilt, Nahum Allon, Tamar Blumenfeld Katzir, Efrat Sasson, Uri Raviv, Haim Ovadia, Yechezkel Barenholz   +9 more
doaj   +2 more sources

Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation

Noise and Health
Objective: To evaluate the clinical effect of retroaural injection of methylprednisolone sodium succinate combined with hyperbaric oxygen (HBO) on the treatment of noise-induced hearing loss.
Yan Yao, Lei Li
doaj   +2 more sources

Remodeling the Inflammatory Microenvironment: Nanomaterial-Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis. [PDF]

Small Sci
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Zhou C, Li J, Zhang J, Wang H, Lu H, Shang S, Li W.   +6 more
europepmc   +2 more sources

Comparing continuous micromixing and extrusion downsizing for PEGylated nanoliposomes remotely loaded with doxorubicin or the steroid pro-drug methylprednisolone hemisuccinate

Journal of Controlled Release
Since the FDA approval of the first nanodrug Doxil® in 1995, twenty subsequent liposome and lipid nanoparticle (LNP) based drugs (of which 10 are nanodrugs), were approved by the FDA. The application of such drug-products was considerably boosted by the mRNA-LNP based vaccines used to stop the COVID-19 pandemic.
Keren, Turjeman, Alexander-Nicholas, Egler-Kemmerer, Dima, Shamrakov, Christine, Paulus, Raphael, Thiermann, Yechezkel, Barenholz, Regina, Bleul   +6 more
openaire   +3 more sources

Acute renal failure in a patient with epidermolysis bullosa acquisita [PDF]

Anais Brasileiros de Dermatologia, 2017
: Epidermolysis bullosa acquisita is a severe autoimmune subepidermal bullous disease. In this report, we described for the first time a patient with epidermolysis bullosa acquisita who developed acute renal failure.
Guowei Zhao, Qing Yang, Furen Zhang
doaj   +1 more source

Simultaneous analysis of 44 frequently abused corticosteroid drugs using polysaccharide‐based chiral column‐HRMS approach

Analytical Science Advances, Volume 2, Issue 9-10, Page 427-439, October 2021., 2021
Abstract Corticoids have found their way into the globe of sports, due to their anti‐inflammatory properties, and have often found to be added to dietary supplements for illegally improving the effectiveness of their products. Earlier studies describe the detection of corticoids in several matrices, but this can be an incessant and continuous process ...
Abdul Khader Karakka Kal, Tajudheen K. Karatt, Jahfar Nalakath, Michael Benedict Subhahar, Shino Ann Koshy, Zubair Perwad, Muhammed Ajeebsanu M.P   +6 more
wiley   +1 more source

Repair of Osteoporotic Bone Defects Using Adipose‐Derived Stromal Cells and Umbilical Vein Endothelial Cells Seeded in Chitosan/Nanohydroxyapatite‐P24 Nanocomposite Scaffolds

Journal of Nanomaterials, Volume 2021, Issue 1, 2021., 2021
Background. The cell regeneration and blood supply of bone defect lesions are restricted under osteoporotic pathological conditions, which make the healing of bone defect of osteoporosis still a great challenge. The current therapeutic strategies that mainly inhibit bone resorption are not always satisfactory for osteoporotic bone defects, which make ...
Yifei Fang, Yong Gong, Zhijian Yang, Yan Chen, Hui Qi Xie   +4 more
wiley   +1 more source