Results 131 to 140 of about 1,431,476 (287)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Assouad Dimension, Nagata Dimension, and Uniformly Close Metric Tangents
, 2015 We study the Assouad dimension and the Nagata dimension of metric spaces. As a general result, we prove that the Nagata dimension of a metric space is always bounded from above by the Assouad dimension.
Rajala, Tapio, Le Donne, Enrico
core +1 more source
Metric Dimension of Graphs Djembe (Dj_n)
InPrimeLet G=(V,E) be a connected graph. For an ordered set A⊆V(G), the representation of a vertex with respect to A is defined by its distance vector to the vertices of A.
Duratul Hayat +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Metric dimension of ultrametric spaces
, 2020 For an arbitrary finite metric space \((X,d)\) a subset \(A\), \(A \subset X\), is called a resolving set if for any two points \(x\) and \(y\) from the space \(X\) there is an element \(a\) from subset \(A\), such that distances \(d(a,x)\) and \(d(
Oliynyk, Bogdana, Ponomarchuk, Bogdan
core
Nonlocal Metric Dimension of Windmill Graph
Jurnal DiferensialLet G = (V (G), E(G)) be a simple and connected graph. The distance between two vertices u and v in G, is the length of a shortest path from u to v, denoted by d(u, v).
Fithri Annisatun Lathifah
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source