Results 41 to 50 of about 41,474 (267)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Geometry of Weak Metric f-Manifolds: A Survey

Mathematics
The interest of geometers in f-structures is motivated by the study of the dynamics of contact foliations, as well as their applications in physics. A weak f-structure on a smooth manifold, introduced by the author and R. Wolak, generalizes K.
Vladimir Rovenski
doaj   +1 more source

Geometry of $H$-paracontact metric manifolds [PDF]

Publicationes Mathematicae Debrecen, 2015
We introduce and study $H$-paracontact metric manifolds, that is, paracontact metric manifolds whose Reeb vector field $ $ is harmonic. We prove that they are characterized by the condition that $ $ is a Ricci eigenvector. We then investigate how harmonicity of the Reeb vector field $ $ of a paracontact metric manifold is related to some other ...
CALVARUSO, Giovanni, PERRONE, Domenico
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Deforming black holes in AdS

Journal of High Energy Physics, 2018
We investigate how changes in the boundary metric affect the shape of AdS black holes. Most of our work is analytic and based on the AdS C-metric. Both asymptotically hyperbolic and compact black holes are studied. It has recently been shown that the AdS
Gary T. Horowitz, Jorge E. Santos, Chiara Toldo   +2 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Geometry of Hamiltonian Dynamics with Conformal Eisenhart Metric

International Journal of Mathematics and Mathematical Sciences, 2011
We characterize the geometry of the Hamiltonian dynamics with a conformal metric. After investigating the Eisenhart metric, we study the corresponding conformal metric and obtain the geometric structure of the classical Hamiltonian dynamics. Furthermore,
Linyu Peng, Huafei Sun, Xiao Sun
doaj   +1 more source

Equiaffine Braneworld

Galaxies, 2020
Higher dimensional theories, wherein our four dimensional universe is immersed into a bulk ambient, have received much attention recently, and the directions of investigation had, as far as we can discern, all followed the ordinary Euclidean hypersurface
Fan Zhang
doaj   +1 more source