Results 151 to 160 of about 6,713,503 (368)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Metric spaces and textures

open access: yesApplied General Topology, 2017
<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Textures are point-set setting for fuzzy sets, and they provide a framework for the complement-free mathematical concepts. Further dimetric on textures is a gener- alization of classical metric spaces.
openaire   +5 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

On partial metric spaces and partial cone metric spaces

open access: yesHacettepe Journal of Mathematics and Statistics, 2017
It this article we shall show that partial metric spaces and partial cone metric spaces are quasi-uniformizable and hence quasi-metrizable. Finally, an application to the Banach’s fixed point theorem will be presented in this context.
openaire   +3 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

The space of Lorentz metrics

open access: yesCommunications in Mathematical Physics, 1973
The set of allC 2 Lorentz metrics on a non-compact four-manifold is given the Whitney fineC 2 topology. It is shown that this provides the correct framework within which to discuss the global properties of spacetime manifolds in general, and the singularity theorems in particular. The main result is a theorem showing that the Robertson-Walker big bang (
openaire   +4 more sources

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