Results 51 to 60 of about 41,328 (259)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Neutrosophic Partial Metric Spaces and Fixed Point Theorems

Journal of Function Spaces
In this paper, neutrosophic partial metric spaces are defined, and their basic properties and examples are obtained. Furthermore, the relations between neutrosophic partial metric spaces, classical metric spaces, fuzzy partial metric spaces, and fuzzy ...
Abdullah Kargın
doaj   +1 more source

On the C∗ -algebra valued G-metric space related with fixed point theorems

Қарағанды университетінің хабаршысы. Математика сериясы, 2019
There are many fixed point results in the various kinds of metric spaces such as b - metric spaces, quaternion metric spaces, G-metric spaces, uniform spaces, non - commutative Banach spaces etc. In this work, we consider the one of modern methods as C*-
Ozen ¨ Ozer, Saleh Omran
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fixed-Point Results with Applications in Generalized Neutrosophic Rectangular b-Metric Spaces

Axioms
In this paper, we introduce several new concepts: generalized neutrosophic rectangular b-metric-like spaces (GNRBMLSs), generalized intuitionistic rectangular b-metric-like spaces (GIRBMLSs), and generalized fuzzy rectangular b-metric-like spaces ...
Nawab Hussain, Nawal Alharbi, Ghada Basendwah   +2 more
doaj   +1 more source

Some Extensions of Fixed Point Results over Quasi-JS-Spaces

Journal of Function Spaces, 2016
We introduce the notion of quasi-JS-metric space. After defining the basic topological properties of quasi-JS-metric space, we investigate fixed point of certain mapping in the frame of complete quasi-JS-metric space.
Maha Noorwali, Hamed H. Alsulami, Erdal Karapınar   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Fixed Point Theorems in Complex Valued B-Metric Spaces

Cauchy: Jurnal Matematika Murni dan Aplikasi, 2017
A complex-valued b-metric space is a generalization of a b-metric space in which its b-metric space has complex value. It can also be considered as a generalization of a complex-valued metric space. Hence, fixed point theorems that have been studied in b-
Dahliatul Hasanah
doaj   +1 more source