Results 71 to 80 of about 67,599 (265)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fixed Point Theorems in Complex Valued B-Metric Spaces

Cauchy: Jurnal Matematika Murni dan Aplikasi, 2017
A complex-valued b-metric space is a generalization of a b-metric space in which its b-metric space has complex value. It can also be considered as a generalization of a complex-valued metric space. Hence, fixed point theorems that have been studied in b-
Dahliatul Hasanah
doaj   +1 more source

Convexity in quasi-metric spaces

, 2012
Includes abstract.Includes bibliographical references.The principal aim of this thesis is to investigate the existence of an injective hull in the categories of T-quasi-metric spaces and of T-ultra-quasi-metric spaces with nonexpansive ...
Otafudu, Olivier Olela
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Equivalence of some results and fixed-point theorems in S-multiplicative metric spaces

Fixed Point Theory and Algorithms for Sciences and Engineering
In this paper, some fixed-point theorems are stated and proved in S-multiplicative metric spaces. We also show in this paper that some fixed-point results for various S-multiplicative metric spaces are equivalent to those of corresponding fixed-point ...
Olusola Kayode Adewale, Samuel Olusola Ayodele, Babatunde Eriwa Oyelade, Emmanuella Ehui Aribike   +3 more
doaj   +1 more source

Common fixed point theorems for cyclic contractive mappings in partial cone b-metric spaces and applications to integral equations

Nonlinear Analysis, 2016
In this paper, we introduce the concept of partial cone b-metric spaces as a generalization of partial metric, cone metric and b-metric spaces and establish some topological properties of partial cone b-metric spaces.
Chuanxi Zhu, Wenqing Xu, Tatjana Došenovič, Zorana Golubovic   +3 more
doaj   +1 more source

Hyperconvexity and endpoints in T₀-quasi-metric spaces

, 2013
Over the last decades much progress has been made in the investigation of hyperconvexity in metric spaces. Recently Kemajou and others have published an article concerning hyperconvexity in T₀-quasi-metric spaces.
Haihambo, Paulus
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Property A and CAT(0) cube complexes

, 2009
Property A is a non-equivariant analogue of amenability defined for metric spaces. Euclidean spaces and trees are examples of spaces with Property A.
Wright, N.J., Campbell, S.J., Brodzki, J., Guentner, E., Niblo, G.A.   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source