Results 81 to 90 of about 45,851 (264)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A Version of the Hahn-Banach Theorem for R-Vector Spaces [PDF]

Sahand Communications in Mathematical Analysis
Recently, $R$-metric spaces have been introduced to generalized metric spaces. This extension is based on the construction of a new universe with interesting properties.
Azadeh Alijani, Zohreh Heydarpour, Maryam Naderi Parizi   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

On multiplicative modular metric spaces of Kaplan et al.: corrections and clarifications

Fixed Point Theory and Algorithms for Sciences and Engineering
Kaplan et al. (J. Inequal. Appl. 2025:54, 2025) introduced the notion of multiplicative modular metric spaces, motivated by the framework of multiplicative metric spaces (Özavşar and Cevikel in J. Eng. Technol. Appl. Sci.
Satit Saejung
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Some ϕ-fixed point results in b-metric spaces with applications

Cumhuriyet Science Journal, 2019
The fixed point theory is the most important topic in mathematics anaysis. This topic has many applications in the different fields. It demonstrates the uniqueness of the existence of a mapping and how it can be found.
Müzeyyen Sangurlu Sezen
doaj   +1 more source

An Extended b-Metric-Type Space and Related Fixed Point Theorems with an Application to Nonlinear Integral Equations

Advances in Mathematical Physics, 2020
In this paper, the concept of sequential p-metric spaces has been introduced as a generalization of usual metric spaces, b-metric spaces and specially of p-metric spaces. Several topological properties of such spaces have been discussed here.
Kushal Roy, Sayantan Panja, Mantu Saha, Vahid Parvaneh   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source