Results 91 to 100 of about 67,599 (265)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

An Extended b-Metric-Type Space and Related Fixed Point Theorems with an Application to Nonlinear Integral Equations

open access: yesAdvances in Mathematical Physics, 2020
In this paper, the concept of sequential p-metric spaces has been introduced as a generalization of usual metric spaces, b-metric spaces and specially of p-metric spaces. Several topological properties of such spaces have been discussed here.
Kushal Roy   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

The role of funnels and punctures in the Gromov hyperbolicity of Riemann surfaces [PDF]

open access: yes, 2006
27 pages, no figures.-- MSC2000 codes: 30F20, 30F45.MR#: MR2243795 (2007e:30063)Zbl#: Zbl 1108.30031We prove results on geodesic metric spaces which guarantee that some spaces are not hyperbolic in the Gromov sense.
Tourís, Eva   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Some ϕ-fixed point results in b-metric spaces with applications

open access: yesCumhuriyet Science Journal, 2019
The fixed point theory is the most important topic in mathematics anaysis. This topic has many applications in the different fields. It demonstrates the uniqueness of the existence of a mapping and how it can be found.
Müzeyyen Sangurlu Sezen
doaj   +1 more source

partial translation algebras for certain discrete metric spaces

open access: yes, 2010
The notion of a partial translation algebra was introduced by Brodzki, Nibloand Wright in [11] to provide an analogue of the reduced group C*-algebrafor metric spaces.
Putwain, Rosemary Johanna
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

On multiplicative modular metric spaces of Kaplan et al.: corrections and clarifications

open access: yesFixed Point Theory and Algorithms for Sciences and Engineering
Kaplan et al. (J. Inequal. Appl. 2025:54, 2025) introduced the notion of multiplicative modular metric spaces, motivated by the framework of multiplicative metric spaces (Özavşar and Cevikel in J. Eng. Technol. Appl. Sci.
Satit Saejung
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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