Results 91 to 100 of about 8,611,490 (324)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

From homogeneous metric spaces to Lie groups

Comptes Rendus. Mathématique
We study homogeneous metric spaces, by which we mean connected, locally compact metric spaces whose isometry group acts transitively.After a review of a number of classical results, we use the Gleason–Iwasawa–Montgomery–Yamabe–Zippin structure theory to ...
Cowling, Michael G., Kivioja, Ville, Le Donne, Enrico, Nicolussi Golo, Sebastiano, Ottazzi, Alessandro   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Multi-valued mappings on Pompeiu-Hausdorff fuzzy b-metric spaces and a common fixed point result

Vojnotehnički Glasnik
Introduction/purpose: The study of the theory of fuzzy sets was prompted by the presence of uncertainty as an essential part of real-world problems, leading Zadeh to address the problem of indeterminacy. The notion of fuzzy logic was introduced by Zadeh.
Noreddine Makran, Stojan N. Radenović
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Some Topological Characteristics of q-Rung Orthopair Fuzzy Metric Space

Advances in Fuzzy Systems
This paper introduced a novel concept of q-rung orthopair fuzzy (q-ROF) metric spaces, in connection with the idea of q-ROF sets, which generalizes well-known concepts of fuzzy metric spaces and intuitionistic fuzzy metric spaces.
Lariab Shahid, Maliha Rashid, Akbar Azam, Aftab Hussain, Ghada Ali Basendwah   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Constant Distortion Embeddings of Symmetric Diversities

Analysis and Geometry in Metric Spaces, 2016
Diversities are like metric spaces, except that every finite subset, instead of just every pair of points, is assigned a value. Just as there is a theory of minimal distortion embeddings of fiite metric spaces into L1, there is a similar, yet undeveloped,
Bryant David, Tupper Paul F.
doaj   +1 more source