Results 101 to 110 of about 8,611,490 (324)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A METRIC THEORY OF MINIMAL GAPS [PDF]
Mathematika, 2018 Comment: Version 2: Fixed a small bug pointed out by Niclas Technau in the statement of section 3, and added references to few gaps in sequences of fractional parts suggested by Andrew ...
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A Note on tvs-G-Cone Metric Fixed Point Theory
Journal of Applied Mathematics, 2012 For a tvs-G-cone metric space (𝑋,𝐺) and for the family 𝒜 of subsets of X, we introduce a new notion of the tvs-ℋ-cone metric ℋ with respect to G, and we get a fixed result for the 𝒞ℬ𝒲-tvs-G-cone-type function in a complete tvs-G-cone metric space (𝒜,ℋ ...
Ing-Jer Lin +3 more
doaj +1 more source
M-theory exotic scalar glueball decays to mesons at finite coupling
Journal of High Energy Physics, 2018 Using the pull-back of the perturbed type IIA metric corresponding to the perturbation of [1]’s M-theory uplift of [2]’s UV-complete top-down type IIB holographic dual of large-N thermal QCD, at finite coupling, we obtain the interaction Lagrangian ...
Vikas Yadav, Aalok Misra
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Twisted massive non-compact models
Journal of High Energy Physics, 2018 We study interacting massive N = (2, 2) supersymmetric field theories in two dimensions which arise from deforming conformal field theories with a continuous spectrum.
Songyuan Li, Jan Troost
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Nonlinear potential theory on metric spaces
Illinois Journal of Mathematics, 2002 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kinnunen, Juha, Martio, Olli
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