Results 121 to 130 of about 5,790,959 (300)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The cycle contraction mapping theorem [PDF]
This report lays the foundation for a theory of total correctness for programs not based upon termination. The Cycle Contraction Mapping Theorem is both an extension of Wadge's cycle sum theorem for Kahn data flow and a generalisation of Banach's ...
Matthews, Stephen G.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Weighted metric multidimensional scaling [PDF]
This paper establishes a general framework for metric scaling of any distance measure between individuals based on a rectangular individuals-by-variables data matrix. The method allows visualization of both individuals and variables as well as preserving
Michael Greenacre
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The DCU dependency-based metric in WMT-MetricsMATR 2010 [PDF]
, 2010 We describe DCU’s LFG dependencybased metric submitted to the shared evaluation task of WMT-MetricsMATR 2010. The metric is built on the LFG F-structurebased approach presented in (Owczarzak et al., 2007).
He, Yifan +3 more
core +3 more sources
Fundamental Characteristics of the Product-Operated Metric Spaces
AxiomsIn the field of metric fixed point theory, there are several generalized or modified types of metric space. One such type is called multiplicative metric space. It was initially introduced as a modified version of the metric space, but was later found to
Muhammad Usman Ali +3 more
doaj +1 more source
A METRIC SET THEORY WITH A UNIVERSAL SET
The Journal of Symbolic LogicAbstract Motivated by ideas from the model theory of metric structures, we introduce a metric set theory, $\mathsf {MSE}$ , which takes bounded quantification
openaire +2 more sources