Results 61 to 70 of about 108,606 (260)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Revisiting Probabilistic Metric Spaces

International Journal of Topology
The field of probabilistic metric spaces has an intrinsic interest based on a blend of ideas drawn from metric space theory and probability theory. The goal of the present paper is to introduce and study new ideas in this field.
Michael D. Rice
doaj   +1 more source

Double Controlled Partial Metric Type Spaces and Convergence Results

Journal of Mathematics, 2021
In this paper, we firstly propose the notion of double controlled partial metric type spaces, which is a generalization of controlled metric type spaces, partial metric spaces, and double controlled metric type spaces.
Haroon Ahmad, Mudasir Younis, Mehmet Emir Köksal   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Multi-valued mappings on Pompeiu-Hausdorff fuzzy b-metric spaces and a common fixed point result

Vojnotehnički Glasnik
Introduction/purpose: The study of the theory of fuzzy sets was prompted by the presence of uncertainty as an essential part of real-world problems, leading Zadeh to address the problem of indeterminacy. The notion of fuzzy logic was introduced by Zadeh.
Noreddine Makran, Stojan N. Radenović
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

From homogeneous metric spaces to Lie groups

Comptes Rendus. Mathématique
We study homogeneous metric spaces, by which we mean connected, locally compact metric spaces whose isometry group acts transitively.After a review of a number of classical results, we use the Gleason–Iwasawa–Montgomery–Yamabe–Zippin structure theory to ...
Cowling, Michael G., Kivioja, Ville, Le Donne, Enrico, Nicolussi Golo, Sebastiano, Ottazzi, Alessandro   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Some Topological Characteristics of q-Rung Orthopair Fuzzy Metric Space

Advances in Fuzzy Systems
This paper introduced a novel concept of q-rung orthopair fuzzy (q-ROF) metric spaces, in connection with the idea of q-ROF sets, which generalizes well-known concepts of fuzzy metric spaces and intuitionistic fuzzy metric spaces.
Lariab Shahid, Maliha Rashid, Akbar Azam, Aftab Hussain, Ghada Ali Basendwah   +4 more
doaj   +1 more source