Results 41 to 50 of about 46,876 (239)

On the Metrical Theory of a Generalized Continued Fraction Expansion

, 2010
This paper has been withdrawn by the authors.
Lascu, Dan, Kawamura, Katsunori
openaire   +2 more sources

On Localized Tachyon Condensation in $\BC^2/\BZ_n$ and $\BC^3/\BZ_n$

, 2004
We study some aspects of localized tachyon condensation on non-supersymmetric orbifolds of the form $\BC^2/\BZ_n$ and $\BC^3/\BZ_n$. We discuss the gauged linear sigma models for these orbifolds. We show how several features of the decay of orbifolds of $
Adams, Aspinwall, Bardakci, Bardakci, Bardakci, Bardakci, Craw, Dabholkar, Dabholkar, Dixon, Douglas, Douglas, Feng, Feng, Fulton, Gregory, Harvey, Headrick, Martinec, Minwalla, Moore, Morrison, Morrison, Muto, Oda, Okawa, Sarkar, Sen, Sin, Tapobrata Sarkar, Vafa, Witten   +31 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

On certain statistical properties of continued fractions with even and with odd partial quotients [PDF]

, 2012
We prove results concerning the joint limiting distribution of the renewal time of denominators and consecutive digits of random irrational numbers in the case of continued fractions with even partial quotients, with odd partial quotients, and for Nakada'
Boca, Florin P., Vandehey, Joseph
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Erd\H{o}s--Moser equation $1^k+2^k+...+(m-1)^k=m^k$ revisited using continued fractions

, 2009
If the equation of the title has an integer solution with $k\ge2$, then $m>10^{9.3\cdot10^6}$. This was the current best result and proved using a method due to L. Moser (1953). This approach cannot be improved to reach the benchmark $m>10^{10^7}$.
Gallot, Yves, Moree, Pieter, Zudilin, Wadim   +2 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Multi-variable Polynomial Solutions to Pell's Equation and Fundamental Units in Real Quadratic Fields

, 2018
For each positive integer $n$ it is shown how to construct a finite collection of multivariable polynomials $\{F_{i}:=F_{i}(t,X_{1},..., X_{\lfloor \frac{n+1}{2} \rfloor})\}$ such that each positive integer whose squareroot has a continued fraction ...
Bernstein, Bernstein, J. Mc Laughlin, Levesque, Schinzel, Schinzel, van der Poorten, van der Poorten   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source