Results 101 to 110 of about 1,384,222 (249)

A burden of proof study on alcohol consumption and ischemic heart disease

Nature Communications
Cohort and case-control data have suggested an association between low to moderate alcohol consumption and decreased risk of ischemic heart disease (IHD), yet results from Mendelian randomization (MR) studies designed to reduce bias have shown either no ...
Sinclair Carr, Dana Bryazka, Susan A. McLaughlin, Peng Zheng, Sarasvati Bahadursingh, Aleksandr Y. Aravkin, Simon I. Hay, Hilary R. Lawlor, Erin C. Mullany, Christopher J. L. Murray, Sneha I. Nicholson, Jürgen Rehm, Gregory A. Roth, Reed J. D. Sorensen, Sarah Lewington, Emmanuela Gakidou   +15 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Using Neural Networks In Software Metrics [PDF]

Software metrics provide effective methods for characterizing software. Metrics have traditionally been composed through the definition of an equation, but this approach is limited by the fact that all the interrelationships among all the parameters be ...
Nicolae Begnescu, Ion I. Bucur
core  

Bayesian inference for a software reliability model using metrics information. [PDF]

, 2001
In this paper, we are concerned with predicting the number of faults N and the time to next failure of a piece of software. Information in the form of software metrics data is used to estimate the prior distribution of N via a Poisson regression model ...
Rodríguez Bernal, María Teresa, Wiper, Michael Peter, Wiper, Michael P., Rodríguez Bernal, M. T.   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A burden of proof study of the effects of exposure to high fasting plasma glucose on the risk of seven types of cancer

Scientific Reports
Cancer is a major public health problem strongly influenced by genetic factors and aging; however, a proportion of its burden can be attributed to potentially modifiable risk factors.
Paula Portal Teixeira, Yvonne Yiru Xu, Aleksandr Aravkin, Peng Zheng, Lisa M. Force, Jonathan Kocarnik, Susan McLaughlin, Theo Vos, Hailey Lenox, Simon I. Hay, Bruce Bartholow Duncan, Verônica Colpani, Chris Murray, Fernando Gerchman, Kanyin Liane Ong   +14 more
doaj   +1 more source

Delays in Blood Work and Disease Burden: A Cross-Sectional Analysis of Unmet Blood Work Need and Seven Key Health Conditions Across 21 Countries

International Journal of Public Health
ObjectivesThis study analyzes survey data across 21 countries to explore correlations between delays in blood testing and the prevalence of seven health conditions: thalassaemias, sickle cell disorders, malaria, HIV, high fasting plasma glucose, impaired
Eunice Chung, Louisa Ewald, Nicholas J. Kassembaum, Nicholas J. Kassembaum, Taylor Noyes, Emmanuela Gakidou, Emmanuela Gakidou, Ali H. Mokdad, Ali H. Mokdad   +8 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An Information Theoretic Evaluation of Software Metrics for Object Lifetime Prediction [PDF]

, 2008
Accurate object lifetime prediction can be exploited by allocators to improve the performance of generational garbage collection by placing immortal or long-lived objects directly into immortal or old generations.
Watson, Ian, Singer, Jeremy, Lujan, Mikel, Brown, Gavin D., Marion, Sebastien, Jones, Richard E., Ryder, Chris   +6 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source