Results 111 to 120 of about 2,496,702 (337)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Comparing 3 Evidence‐Based Strategies to Reduce Cardiovascular Disease Burden: An Individual‐Based Cardiometabolic Policy Simulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Understanding the real‐world impact of clinical trials that change risk factors is important for health policy. We developed a microsimulation that estimates the population‐level benefits in each US state of cardiometabolic interventions ...
Sylvia Lutze, Steve Bachmeier, Alison Bowman, Nicole DeCleene, Hussain Jafari, Matthew Kappel, Caroline Kinuthia, Paulina Lindstedt, Megan Lindstrom, Rajan Mudambi, Christian Razo, Kjell Swedin, Abraham Flaxman, Gregory Roth   +13 more
doaj   +1 more source

Object-Oriented Metrics for Quality Improvement of Object-Oriented Software

, 2020
Mohit Kumar Sharma, Sandeep Ranjan, Amardeep Gupta   +2 more
openalex   +1 more source

On the rescaled Riemannian metric of Cheeger Gromoll type on the cotangent bundle [PDF]

, 2013
Aydın Gezer, Murat Altunbaş
openalex   +1 more source

Prediction of random variables by excursion metric projections [PDF]

, 2022
Vitalii Makogin, Evgeny Spodarev
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Towards Making High Dimensional Distance Metric Learning Practical [PDF]

, 2015
Qi Qian, Rong Jin, Lijun Zhang, Shenghuo Zhu   +3 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Is my automatic audio captioning system so bad? spider-max: a metric to consider several caption candidates

, 2022
Étienne Labbé, Thomas Pellegrini, Julien Pinquier   +2 more
openalex   +1 more source