Results 111 to 120 of about 1,384,222 (249)

Differences across the lifespan between females and males in the top 20 causes of disease burden globally: a systematic analysis of the Global Burden of Disease Study 2021

The Lancet Public Health
Summary: Background: Sex and gender shape health. There is a growing body of evidence focused on comprehensively and systematically examining the magnitude, persistence, and nature of differences in health between females and males.
Vedavati Patwardhan, PhD, Gabriela F Gil, MPH, Alejandra Arrieta, MIDP, Jack Cagney, MSc, Erin DeGraw, MPH, Molly E Herbert, MSc, Mariam Khalil, MSc, Erin C Mullany, BA, Erin M O’Connell, BA, Cory N Spencer, MPH, Caroline Stein, PhD, Aiganym Valikhanova, PhD, Emmanuela Gakidou, ProfPhD, Luisa S Flor, PhD   +13 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Infinite-Centre Gibbons-Hawking Metrics, Applied to Gravitational Instantons and Monopoles [PDF]

, 2010
We investigate the convergence of infinite-centre Gibbons-Hawking metrics, in the contexts of four-dimensional gravitational instantons and their applications, Kaluza-Klein monopoles and vortices, gravitational calorons, analytical extensions of Majumdar-
RUTLIDGE, KATIE
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Validation of Metrics for Collaborative Systems [PDF]

This paper describe the new concepts of collaborative systems metrics validation. The paper define the quality characteristics of collaborative systems. There are proposed a metric to estimate the quality level of collaborative systems.
Ion IVAN, Cristian CIUREA
core  

Health literacy and mental health: a national cross-sectional inquiry

Scientific Reports
Health literacy and mental health are among the most important issues in the modern health and era of public health. This study aimed to investigate the association between health literacy and mental health status.
Aliasghar Haeri-Mehrizi, Samira Mohammadi, Shahram Rafifar, Jila Sadighi, Ramin Mozaffari Kermani, Rahele Rostami, Akram Hashemi, Mahmoud Tavousi, Ali Montazeri   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

On the Geroch-Traschen class of metrics

, 2009
We compare two approaches to semi-Riemannian metrics of low regularity. The maximally 'reasonable' distributional setting of Geroch and Traschen is shown to be consistently contained in the more general setting of nonlinear distributional geometry in the
Steinbauer, R., Vickers, J.A.
core   +1 more source

Simulated data for census-scale entity resolution research without privacy restrictions: a large-scale dataset generated by individual-based modeling [version 2; peer review: 1 approved, 2 approved with reservations]

Gates Open Research
Background Entity resolution (ER) is the process of identifying and linking records that refer to the same real-world entity. ER is a fundamental challenge in data science, and a common barrier to ER research and development is that the data fields used ...
Abraham Flaxman, Rajan Mudambi, Beatrix Haddock, Nathaniel Blair-Stahn, Alix Pletcher, Matt Kappel, Os Keyes, Syl Lutze, Steve Bachmeier, Alison Bowman, James Albright, Zeb Burke-Conte, Caroline Kinuthia   +12 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source