Results 111 to 120 of about 2,231,192 (331)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
The Metric and British Systems of Weights, Measures and Coinage [PDF]
, 1907 F. Mollwo Perkin
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FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Journal of Geometric Analysis, 2012 We introduce a new biholomorphically invariant metric based on Fefferman's invariant Szego kernel and investigate the relation of the new metric to the Bergman and Carath odory metrics. A key tool is a new absolutely invariant function assembled from the Szego and Bergman kernels.
David E. Barrett, Lina Lee
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Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Classical and Quantum Gravity, 2015 37 pages. Submitted to Classical and Quantum Gravity for its "Milestones of General Relativity" focus issue to be published during the Centenary Year of GR.
openaire +6 more sources
Weights and Measures in England Versus the Decimal and Metric Systems [PDF]
, 1892 J. James Cousins
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