Results 191 to 200 of about 1,662,806 (238)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Global Burden of Diseases Attributed to Low Vegetable Consumption: A Secondary Analysis Based on the Global Burden of Disease 2023 Study

Current Developments in Nutrition
Demowoz Haile, Michael D Brauer, Kassandra L Harding, Ana Pereda, Jeffrey D Stanaway   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

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Metrics, Metrics, Metrics, Part 2: Universal Metrics?

IEEE Intelligent Systems, 2010
A previous article in this department from 2008 introduced the topic of measures and metrics. The focus of that essay was on measurement of the "negative hedonics" of work-the frustrations, uncertainties, mistrust, and automation surprises caused by poorly designed technology that is not human-centered.
Hoffman, Robert R., Hancock, Peter A., Bradshaw, Jeffrey M.   +2 more
openaire   +2 more sources

Metrics, Metrics, Metrics: Negative Hedonicity

IEEE Intelligent Systems, 2008
Intelligent technologies such as performance support systems and decision aids represent a key aspect of modern sociotechnical systems. When new tools are introduced into the workplace, they represent hypotheses about how cognitive work is expected to change.
Hoffman, Robert R., Hancock, Peter, Marx, Morris   +2 more
openaire   +2 more sources

Metrics, quasi-metrics, hemi-metrics

2013
Metrics, hemi-metrics, and open balls A natural instance of topological space is given by metric spaces , as already studied in Chapter 3. Note that metrics are symmetric: the distance between x and y is the same as the distance between y and x .
openaire   +1 more source

Assessment methods and performance metrics for redox flow batteries

Nature Energy, 2021
Yang Shi, Yi-Chun Lu
exaly  

Metrics, Metrics, Metrics

Journal of the American College of Radiology, 2016
openaire   +2 more sources