Results 11 to 20 of about 2,654 (164)

Paraspinal Extrarenal Wilms Tumor Case Report and Review of Literature. [PDF]

Case Rep Pediatr
Introduction Extrarenal Wilms tumors (ERWTs) (i.e., nephroblastoma) are exceptionally rare tumors that have only been reported approximately 100 times in the literature. These tumors necessitate histology (rather than imaging) for proper identification, often resulting in a postoperative diagnosis.
Barbaro JL, Borowicz VM, Klein BJ, Emanuel AJ.   +3 more
europepmc   +2 more sources

The Importance of Trigeminal Cisternography in the Percutaneous Treatment of Idiopathic Trigeminal Neuralgia. [PDF]

Pain Res Manag
Objective: To investigate whether the tip of the spinal needle was accurately positioned within the trigeminal cistern (TC) in patients with idiopathic trigeminal neuralgia undergoing percutaneous treatments through the foramen ovale. Methods: Transovale trigeminal cisternography (TOTC) was performed to ascertain the location of the spinal needle tip ...
Balevi M.
europepmc   +2 more sources

Histodenz Separation of Lysosomal Subpopulations for Analysis of Chaperone-mediated Autophagy. [PDF]

Curr Protoc
Abstract Chaperone‐mediated autophagy (CMA) is the most selective form of lysosomal proteolysis, in which proteins are individually selected for lysosomal degradation. CMA degradation targets bear a pentapeptide consensus motif that is recognized by the cytosolic chaperone HSPA8 (Hsc70), which participates in the trafficking of the target to the ...
Burns CM, Miller RA, Endicott SJ.
europepmc   +2 more sources

Breastfeeding and contrast agents-A critical review and presentation of new aspects. [PDF]

Fundam Clin Pharmacol
Abstract Background There are discrepancies between guidelines of scientific societies and information of the package inserts of contrast media concerning breastfeeding following the application of a contrast agent to the mother. Objectives The contents of different review articles reflect the opinion of scientific societies.
Lemmenmeier S, Boehm I.
europepmc   +2 more sources

Differences in radiopacity among CT contrast agents and concentrations: A quantitative study

Journal of Neuroimaging, Volume 33, Issue 6, Page 909-916, November/December 2023., 2023
Abstract Background and purpose Several studies in the literature have attempted to subjectively assess the degree of visualization of different neurovascular structures using different contrast agents and concentrations. Given the recent contrast shortages, we aim to objectively compare the radiopacity achieved with four angiographic contrast agents ...
Amit Mehta, Jorge A. Roa, Kelly Cannavale, Samir Sur, I. Paul Singh   +4 more
wiley   +1 more source

The lysosomal proteome of senescent cells contributes to the senescence secretome

Aging Cell, Volume 21, Issue 10, October 2022., 2022
Here, we report that senescent cells upregulate the two major types of autophagy, chaperone‐mediated autophagy, and macroautophagy. We analyze the proteome of lysosomes engaged in each pathway, identifying novel markers of senescent cells. We also report that some senescent cells can perform direct lysosomal exocytosis by which lysosomal components ...
Miguel Rovira, Rebecca Sereda, David Pladevall‐Morera, Valentina Ramponi, Ines Marin, Mate Maus, Julio Madrigal‐Matute, Antonio Díaz, Fernando García, Javier Muñoz, Ana María Cuervo, Manuel Serrano   +11 more
wiley   +1 more source

Construction of an immune-related prognostic model and potential drugs screening for esophageal cancer based on bioinformatics analyses and network pharmacology. [PDF]

Immun Inflamm Dis
Flow diagram of this study. Abstract Background Esophageal cancer (ESCA) is a highly invasive malignant tumor with poor prognosis. This study aimed to discover a generalized and high‐sensitivity immune prognostic signature that could stratify ESCA patients and predict their overall survival, and to discover potential therapeutic drugs by the ...
Qi P, Qi B, Gu C, Huo S, Dang X, Liu Y, Zhao B.   +6 more
europepmc   +2 more sources

Proteomics Insights Into Lysosome Biogenesis and Maturation. [PDF]

Proteomics
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Hirn K, Fajardo-Callejón S, Winter D.
europepmc   +2 more sources

Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone-Mediated Autophagy. [PDF]

J Cell Mol Med
ABSTRACT Calcium dysregulation is closely associated with cancer cell proliferation, migration, and invasion. Transient receptor potential canonical 1 (TRPC1) plays an essential role in regulating calcium homeostasis. However, the role of TRPC1 in calcium dysregulation in gliomas remains incompletely understood. In this study, we demonstrate that TRPC1
Chen J, Lai Y, Li M, Cai Z, Lu R, Liu L, Peng Y, Fu C, Xie Z, Zhou X, Liu J, Zhang H.   +11 more
europepmc   +2 more sources

Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
This study investigated the effect of anthracycline antibiotics, mitomycin C, and menadione on oxygen consumption and hydrogen peroxide production by intact, beating, rat heart myocytes. Doxorubicin produced a dose‐dependent increase in the rate of cyanide‐resistant respiration by beating myocytes. The anthracycline analogs 4‐demethoxydaunorubicin, 4 ′‐
James H. Doroshow, Eleonora Cianflone
wiley   +1 more source