Results 21 to 30 of about 2,654 (164)

The E3 ubiquitin ligase MuRF2 attenuates LPS‐induced macrophage activation by inhibiting production of inflammatory cytokines and migration

FEBS Open Bio, Volume 8, Issue 2, Page 234-243, February 2018., 2018
The muscle RING finger (MuRF) family of proteins are E3 ubiquitin ligases that have previously been thought to be expressed only in striated muscle tissue. In this study, we showed that MuRF2 may weaken lipopolysaccharide‐induced macrophage activation by suppressing the production of proinflammatory cytokines and cell migration.
Hongjun Bian, Shanshan Gao, Di Zhang, Qi Zhao, Feifei Li, Xiao Li, Shuohuan Sun, Shouyang Song, Tao Li, Qiang Zhu, Wanhua Ren, Chengyong Qin, Jianni Qi   +12 more
wiley   +1 more source

Vasogenic Cerebral Edema following CT Myelogram with Nonionic Omnipaque 300

Case Reports in Neurological Medicine, Volume 2018, Issue 1, 2018., 2018
Computed Tomography (CT) with myelogram is a relatively safe procedure. It requires the use of nonionic contrast agents which, unlike ionic contrast agents, have been associated with low complication rates. We report a case of a 69‐year‐old female who developed diffuse bilateral cerebral edema following a lumber myelogram with the use of intrathecal ...
Sara Khodor, Scott Blumenthal, Dennis J. Rivet   +2 more
wiley   +1 more source

CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction

Journal of Immunology Research, Volume 2016, Issue 1, 2016., 2016
Chronic liver allograft dysfunction (CLAD) remains the most common cause of patient morbidity and allograft loss in liver transplant patients. However, the pathogenesis of CLAD has not been completely elucidated. By establishing rat CLAD models, in this study, we identified the informative CLAD‐associated genes using isobaric tags for relative and ...
Jing Li, Bin Liu, Yuan Shi, Ke-Liang Xie, Hai-Fang Yin, Lu-nan Yan, Wan-yee Lau, Guo-Lin Wang, Ghislain Opdenakker   +8 more
wiley   +1 more source

Isolation of human salivary extracellular vesicles by iodixanol density gradient ultracentrifugation and their characterizations

Journal of Extracellular Vesicles, Volume 5, Issue 1, January 2016., 2016
Diagnostic methods that focus on the extracellular vesicles (EVs) present in saliva have been attracting great attention because of their non‐invasiveness. EVs contain biomolecules such as proteins, messenger RNA (mRNA) and microRNA (miRNA), which originate from cells that release EVs, making them an ideal source for liquid biopsy.
Kazuya Iwai, Tamiko Minamisawa, Kanako Suga, Yasutomo Yajima, Kiyotaka Shiba   +4 more
wiley   +1 more source

Improved technique for cervical metrizamide myelography

, 1980
Introduction of metrizamide into the lumbar subarachnoid space with the patient in a prone 15-20 degree head-down position improves delivery of contrast material for cervical myelography.
Post, J D, Quencer, R M, Kaplan, J O, Stokes, N A   +3 more
core   +1 more source

Malignant Cerebral Edema following CT Myelogram Using Isovue‐M 300 Intrathecal Nonionic Water‐Soluble Contrast: A Case Report

Radiology Research and Practice, Volume 2011, Issue 1, 2011., 2011
Lumbar myelogram utilizing nonionic contrast is a commonly performed procedure to identify spinal pathology. Complication rates are low. Cerebral edema has been shown to occur following intrathecal injection of ionic contrast; however, no current literature has documented this complication relating to the ubiquitously used nonionic contrast medium.
Brian C. Kelley, Simon Roh, Philip L. Johnson, Paul M. Arnold, Weili Lin   +4 more
wiley   +1 more source

Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging

Journal of Aging Research, Volume 2011, Issue 1, 2011., 2011
Mitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging. Mass spectrometry‐based proteomics suggests itself as a convenient large‐scale
Lisa Staunton, Kathleen O′Connell, Kay Ohlendieck, Alberto Sanz   +3 more
wiley   +1 more source

Activating AMPK improves pathological phenotypes due to mtDNA depletion

The FEBS Journal, Volume 292, Issue 9, Page 2359-2380, May 2025.
In a cellular model of mitochondrial disease characterized by progressive mitochondrial DNA (mtDNA) depletion, we found that advancing mitochondrial dysfunction triggers the early and specific activation of the mitochondria‐associated pool of AMP‐activated protein kinase (AMPK), a master regulator of energy homeostasis.
Gustavo Carvalho, Tran V. H. Nguyen, Bruno Repolês, Josefin M. E. Forslund, W. M. Ruchitha Rukmal Wijethunga, Farahnaz Ranjbarian, Isabela C. Mendes, Choco Michael Gorospe, Namrata Chaudhari, Micol Falabella, Mara Doimo, Sjoerd Wanrooij, Robert D. S. Pitceathly, Anders Hofer, Paulina H. Wanrooij   +14 more
wiley   +1 more source

Signal transduction pathways in mast cell granule‐mediated endothelial cell activation

Mediators of Inflammation, Volume 12, Issue 2, Page 79-87, 2003., 2003
Background: We have previously shown that incubation of human endothelial cells with mast cell granules results in potentiation of lipopolysaccharide‐induced production of interleukin‐6 and interleukin‐8. Aims: The objective of the present study was to identify candidate molecules and signal transduction pathways involved in the synergy between mast ...
Luqi Chi, Lisa Stehno-bittel, Irina Smirnova, Daniel J Stechschulte, Kottarappat N. Dileepan   +4 more
wiley   +1 more source

Intraoperative spinal sonography: adjunct to metrizamide CT in the assessment and surgical decompression of posttraumatic spinal cord cysts

, 1984
Ten patients with prior spinal cord trauma were examined preoperatively by metrizamide computed tomography (CT) and were studied subsequently by intraoperative spinal sonography.
Green, B A, Eismont, F J, Brost, P, Quencer, R M, Morse, B M   +4 more
core   +1 more source