Results 101 to 110 of about 149,141 (380)

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman   +14 more
wiley   +1 more source

Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome [PDF]

open access: yes, 2016
Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL ...
Remon, Jean Paul   +2 more
core   +4 more sources

Comparison of the Effects of Myrtus Communis L, Berberis Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis.

open access: yesJournal of clinical and diagnostic research : JCDR, 2016
INTRODUCTION There is a growing tendency towards herbal medicines for treatment of vaginitis. Antibacterial and antifungal effects of Myrtus communis L and Berberis vulgaris have been demonstrated invitro and invivo. AIM This study aimed to compare the
M. Masoudi, S. Miraj, M. Rafieian-kopaei
semanticscholar   +1 more source

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr   +4 more
wiley   +1 more source

EFEK KLINIS APLIKASI SUBGINGIVAL RACIKAN GEL METRONIDASOL 25% DAN LARUTAN POVIDON-IODIN 10% SEBAGAI TERAPI PENUNJANG SKELING-PENGHALUSAN AKAR PADA PERIODONTITIS KRONIS

open access: yesJournal of Dentistry Indonesia, 2015
Metronidazole gel 25% as an adjunct to scaling and root planing showed clinical effect better than scaling and root-planing alone. In Indonesia metronidazole gel is not popular, since probably it is expensive and not easy to obtain.
Trijani Suwandi
doaj   +1 more source

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro [PDF]

open access: yes, 2019
There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens.
Bernaerts, Kristel   +7 more
core   +2 more sources

Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole.

open access: yesJournal of Infectious Diseases, 2015
Antibiotic administration disrupts the intestinal microbiota, increasing susceptibility to pathogens such as Clostridium difficile. Metronidazole or oral vancomycin can cure C.
Brittany B. Lewis   +8 more
semanticscholar   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

open access: yesExploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu   +4 more
wiley   +1 more source

Caveats of Metronidazole Addition for Surgical Site Infection Prophylaxis in Gynecologic Surgeries. [PDF]

open access: yesPharmacol Res Perspect
Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Tran MH, Truong-Nguyen KH.
europepmc   +2 more sources

Photocatalytic degradation of Metronidazole with illuminated TiO2 nanoparticles

open access: yesJournal of Environmental Health Science and Engineering, 2015
Metronidazole (MNZ) is a brand of nitroimidazole antibiotic, which is generally used in clinical applications and extensively used for the treatment of infectious diseases caused by anaerobic bacteria and protozoans.
M. Farzadkia   +4 more
semanticscholar   +1 more source

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