Results 51 to 60 of about 10,171,198 (336)
p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway
Advanced Science, EarlyView.This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa +23 more
wiley +1 more source
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
Identifying Spatial Priority of Ecological Restoration Dependent on Landscape Quality Trends in Metropolitan Areas [PDF]
, 2021 Junda Huang, Yuncai Wang, Lang Zhang
openalex +1 more source
Atomic‐Scale Insights into Yttrium‐Induced Grain Boundary Structure Modification in Al2O3
Advanced Science, EarlyView.Using advanced STEM characterization combined with NNP‐based MCMD calculations, it is revealed that Y segregation at ∑13 Al2O3 GB involves not only simple substitution of Y for Al atoms but also structural adaptation with a change in GB atomic density, leading to minimized excess volume and lowest GB energy.
Jingyuan Yan +7 more
wiley +1 more source
Cartography of interaction fields in and around Brussels: commuting, moves and telephone calls
Brussels Studies, 2017 Using conventional relational data (residential migrations, commutes to and from the workplace) and less conventional relational data (mobile telephony calls), the space in and around the Brussels-Capital Region is partitioned into groups of closely ...
Arnaud Adam +2 more
doaj +1 more source
Advanced Science, EarlyView.Magnesium silicide (Mg2Si) is introduced as a narrow‐bandgap, biodegradable semiconductor for transient electronics. RF‐sputtered and annealed Mg2Si thin films show high intrinsic electrical conductivity and low thermal conductivity. The polycrystalline material undergoes hydrolysis in aquatic and composting environments with minimal cytotoxicity ...
Ji‐Woo Gu +17 more
wiley +1 more source
Brussels Studies, 2017 Using conventional relational data (residential migrations, commutes to and from the workplace) and less conventional relational data (mobile telephony calls), the space in and around the Brussels-Capital Region is partitioned into groups of closely ...
Arnaud Adam +2 more
doaj +1 more source
Creating a Resource Cadaster—A Case Study of a District in the Rhine-Ruhr Metropolitan Area
, 2017 Today, both resource efficiency in general and the efficient use of natural resources specifically in the building sector are major political issues. Recent studies on resource efficiency have found the “anthropogenic stock” of the building sector to ...
Oezlem Oezdemir, K. Krause, A. Hafner
semanticscholar +1 more source
Advanced Science, EarlyView.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song +14 more
wiley +1 more source
Efficient Preservation of Perishable Fruits by Erasable Metal‐Organic Frameworks
Advanced Science, EarlyView.This study presents an erasable Pickering emulsion‐based coating stabilized by metal‐organic frameworks. This washable coating significantly extends fruit shelf life by scavenging ethylene and inhibiting foodborne pathogens, offering a sustainable solution for postharvest.
Liying Yang +7 more
wiley +1 more source