Results 81 to 90 of about 2,936,544 (251)

Thermodynamic Destabilization of Ti-O Solid Solution by H-2 and Deoxygenation of Ti Using Mg

, 2016
Reactive metals including Ti, Zr, Hf, and V, among others, have a strong chemical affinity to oxygen, which makes them difficult to produce and costly to use.
Zhe Huang, Fang, Zhigang Zak, Pei Sun, Zhigang Zak Fang (1520929), Tuoyang Zhang, Yang Xia, Chengshang Zhou, Xia, Yang, Ying Zhang, Zhigang Zak Fang, Zhang, Tuoyang, Ying Zhang (1235337), Tuoyang Zhang (2808976), Pei Sun (115160), Zhang, Ying, Yang Xia (104600), Chengshang Zhou (1520932), Huang, Zhe, Zhou, Chengshang, Sun, Pei, Zhe Huang (133024)   +20 more
core   +1 more source

Numerical study of Ti/Al/Mg three-layer plates on the interface behavior in explosive welding

Science and Engineering of Composite Materials, 2017
In this study, a finite element model of the explosive welding process of three-layer plates composed of Ti/Al/Mg was established, and the interfacial behaviors of three-layer plates were researched. We investigated the influences that affect the quality
Liu Ruifeng, Wang Wenxian, Zhang Tingting, Yuan Xiaodan   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Fabrication and characterization of Ti–12Mo/xAl2O3 bio-inert composite for dental prosthetic applications

Frontiers in Bioengineering and Biotechnology
Introduction: Titanium (Ti)-molybdenum(Mo) composites reinforced with ceramic nanoparticles have recently significant interest among researchers as a new type of bio-inert material used for dental prosthetic applications due to its biocompatibility ...
Hossam. M. Yehia, Ahmed El-Tantawy, Omayma A. Elkady, Ibrahim M. Ghayad, Walid M. Daoush, Walid M. Daoush   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exploring the Tribophysics and Tribochemistry of MoS2 by Sliding MoS2/Ti Composite Coating Under Different Humidity

, 2017
The MoS2 coatings were prepared by unbalanced magnetron sputtering system. Ti was used as the dopant to improve its mechanical properties and oxidation resistance.
Zhang, Guangan, Guangan Zhang, Hao Li, Wang, Liping, Wu, Guizhi, Xia Li, Guizhi Wu, Li, Hao, Liping Wang, Li, Xia   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source