Results 111 to 120 of about 21,152 (221)

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

The mouse genome database (MGD): new features facilitating a model system

, 2007
The mouse genome database ...
James A. Kadin, Carol J. Bult, Joel E. Richardson, Judith A. Blake   +3 more
core   +1 more source

Complement activation products in tears of dry eye and meibomian gland dysfunction

Scientific Reports
Sixty-seven patients (38 woman; median age, 69 years) were enrolled to assess complement activation products (CAPs) in tear fluid with/without dry eye (DE) and with/without meibomian gland dysfunction (MGD).
Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato, Akihito Kasai, Ryo Mukai, Tomoko Omori, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu   +9 more
doaj   +1 more source

Correlation between ocular symptom score and MGD parameters at 2 months postoperatively.

, 2016
Correlation between ocular symptom score and MGD parameters at 2 months postoperatively.
Yuli Park (772773), Hyung Bin Hwang (3189975), Hyun Seung Kim (772775)   +2 more
core   +1 more source

Diagnosis of meibomian gland dysfunction based on spectral convolutional neural network chip

PhotoniX
Dry eye disease (DED) is the most common ocular surface disorder with meibomian gland dysfunction (MGD) as a leading cause. However, precise diagnosis of MGD based on the intrinsic composition remains unattainable, leading to delayed diagnosis and ...
Yue Shi, Tianhao Liu, Shan Yang, Yu Di, Ying Li, Weihong Yu, Yidong Huang, Di Chen, Kaiyu Cui   +8 more
doaj   +1 more source

In vivo MRI with subsequent histology confirmations of intra-TIPS delivery of MGd/trypan-blue mixture (a–d) and trypan-blue only (e–h).

, 2013
MRI manifests the TIPS shunts before intra-TIPS local deliveries of MGd/blue mixture (arrow on a) and trypan-blue only (arrow on e), and the MGd distribution around the shunt (arrow on b) as bright signal after intra-TIPS agent delivery of MGd/blue ...
Han Wang (254423), Tong Zhang (103827), Guixiang Zhang (383795), Patrick Willis (383791), Xiaoming Yang (113295), Stephanie Soriano (344789), Feng Zhang (6548), Karim Valji (383794), Thomas Le (383792), Erik Ray (383793), Yanfeng Meng (332432)   +10 more
core   +1 more source

Integration of MGDS design into the licensing process [PDF]

, 1997
This paper presents an overview of how the Mined Geologic Disposal System (MGDS) design for a potential repository is integrated into the licensing process. The integration process employs a two-told approach: (1) ensure that the MGDS design complies with applicable Nuclear Regulatory Commission (NRC) licensing requirements, and (2) ensure that the ...
openaire   +2 more sources

The Mouse Genome Database (MGD): from genes to mice—a community resource for mouse biology

, 2005
The Mouse Genome Database (MGD) forms the core of the Mouse Genome Informatics (MGI ...
James A. Kadin, Carol J. Bult, Joel E. Richardson, Judith A. Blake   +3 more
core   +2 more sources

The Mouse Genome Database (MGD): a community resource. Status and enhancements. The Mouse Genome Informatics Group.

, 1998
The Mouse Genome Database (MGD) is a comprehensive community database that integrates genetic, genomic and phenotypic information about the laboratory mouse.
Blake, J A, Richardson, J E, Eppig, J T, Davisson, M T   +3 more
core   +1 more source

Noninvasive Ocular Surface Workup in Patients with Meibomian Gland Dysfunction Using Microwave-Heated Eye Bag

Clinical Ophthalmology
Costanza Rossi,1,* Sabrina Vaccaro,1,* Massimiliano Borselli,1 Giovanna Carnovale Scalzo,1 Mario Damiano Toro,2 Vincenzo Scorcia,1 Giuseppe Giannaccare3 1Department of Ophthalmology, University Magna Graecia of Catanzaro, Catanzaro, Italy; 2Eye ...
Rossi C, Vaccaro S, Borselli M, Carnovale Scalzo G, Toro MD, Scorcia V, Giannaccare G   +6 more
doaj