Results 91 to 100 of about 20,152 (283)
Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. [PDF]
, 2006 Arrowsmith is a unique computer-assisted strategy designed to assist investigators in detecting biologically-relevant connections between two disparate sets of articles in Medline.
Bischoff-Grethe, Amanda +11 more
core +3 more sources
Nature Communications, 2016 Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout
Xiaoming Wang +24 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance How the loss of FMRP affects nonneuronal glial development especially underlying mechanisms remains essentially unexplored. By employing astroglial Fmr1 conditional knockout (cKO) mice and human FMRP-deficient astroglia, in the current study,
Yuqin Men +6 more
semanticscholar +1 more source
Acta Neuropathologica, 2015 Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the ...
Jeremy S. Lum +16 more
openaire +5 more sources
Orchestrated activation of mGluR5 and CB1 promotes neuroprotection
Molecular Brain, 2016 The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site. Since both mGluR5 and CB1 promote neuroprotection, we delineated experiments to investigate a possible ...
Batista, Edleusa M L +6 more
openaire +4 more sources
Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity [PDF]
, 2023 Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischaemic stroke, there is no clinically-approved pharmacological treatment that alleviates ...
Bauer, Adam Q +13 more
core +2 more sources
Spinal Teratoma with Recurrent Epileptic Episodes in Adults: A Case Report
Case Reports in NeurologyIntroduction: Spinal teratomas are rare, accounting for nearly 0.2–0.5% of all spinal tumors and 2% of all teratomas. Teratomas at the conus medullaris location do not inherently lead to epilepsy.
Jinlong Wang, Bo Cao
doaj +1 more source
The BOLD signal and neurovascular coupling in autism [PDF]
, 2013 BOLD (blood oxygen level dependent) fMRI (functional magnetic resonance imaging) is commonly used to study differences in neuronal activity between human populations.
Harris, JJ, Reynell, C
core +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Frontiers in Immunology, 2023 TNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with susceptibility to various pathogens that infect the central nervous system.
Izabella B. Q. de Lima +6 more
doaj +1 more source