Activation of mGluR5 Induces Rapid and Long-Lasting Protein Kinase D Phosphorylation in Hippocampal Neurons [PDF]
, 2010 Metabotropic glutamate receptors (mGluRs), including mGluR5, play a central role in regulating the strength and plasticity of synaptic connections in the brain. However, the signaling pathways that connect mGluRs to their downstream effectors are not yet
AM Valverde +24 more
core +1 more source
Structural similarity networks reveal brain vulnerability in dementia
Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by inter‐individual heterogeneity in brain degeneration, limiting diagnostic and prognostic precision. We present a novel framework integrating Morphometric Inverse Divergence (MIND) networks with hierarchical Bayesian large‐scale population modeling to identify individual‐level ...
Marcella Montagnese +9 more
wiley +1 more source
Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice [PDF]
, 2019 Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Carlin, Dan +6 more
core +1 more source
When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]
, 2016 Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core +1 more source
Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism [PDF]
, 2013 BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of autism, a feature that has prompted a widespread use of the model in preclinical autism research.
A Gozzi +78 more
core +3 more sources
Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex [PDF]
, 2014 Background: Endocannabinoids modulate the glutamatergic excitatory transmission by acting as retrograde messengers. A growing body of studies has reported that both signaling systems in the mesocorticolimbic neural circuitry are involved in the ...
Alen, Francisco +10 more
core +3 more sources
Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Cell Death and DiseaseNiemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations.
Ana Toledano-Zaragoza +9 more
doaj +1 more source
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.
PLoS Pathogens, 2017 Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrPC is required for toxicity, suggesting the existence of deleterious PrPC-dependent signaling cascades.
Despoina Goniotaki +10 more
doaj +1 more source
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
core +1 more source
Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5 [PDF]
, 2016 Luis A. Martinez +9 more
openalex +1 more source