Results 121 to 130 of about 20,152 (283)
mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020 Background Glutamatergic system has been known to play a role in the pathogenesis of major depression disorder by inducing N-methyl-d-aspartate receptor-dependent long-term depression (LTD) or metabotropic glutamate receptors (mGluR)-dependent LTD. Here,
Xiangzhi Jiang +3 more
semanticscholar +1 more source
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Anna Di Maio +9 more
wiley +1 more source
Frontiers in Neuroscience, 2015 In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck +3 more
doaj +1 more source
Nature Communications, 2018 Glutamate is a major excitatory neurotransmitter, and impaired glutamate clearance following synaptic release promotes spillover, inducing extra-synaptic signaling.
M. Katz +7 more
semanticscholar +1 more source
mGluR5 is necessary for maintenance of methamphetamine-induced associative learning [PDF]
European Neuropsychopharmacology, 2013 Conditioned place preference (CPP) reflects the significance of contextual cues that are associated with rewarding effects of abused drugs such as methamphetamine (Meth). Glutamate neurotransmission is augmented following exposure to stimulants and associated cues.
T.C. Napier +3 more
openaire +3 more sources
Advanced Science, Volume 12, Issue 20, May 29, 2025.A region‐wise functional connectivity dynamics (FCD) switching index (RFSI) identifies abnormal drivers in ASD across development, linked to salience/ventral attention, default mode, and frontoparietal networks. RFSI changes correlate with transcriptomic and neurotransmitter profiles, and supported by gene‐edited ASD monkeys.
Wei Li +11 more
wiley +1 more source
Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons. [PDF]
PLoS ONE, 2011 Group I metabotropic glutamate receptors (group I mGluRs; mGluR1 and mGluR5) exert diverse effects on neuronal and synaptic functions, many of which are regulated by intracellular Ca(2+). In this study, we characterized the cellular mechanisms underlying
Jong-Woo Sohn +5 more
doaj +1 more source
Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.Abstract INTRODUCTION In Alzheimer's disease (AD), fibrillar tau gradually progresses from initial seed to larger brain area. However, those brain properties underlying the region‐dependent susceptibility to tau accumulation remain unclear. METHODS We constructed multimodal spatial gradients to characterize molecular properties and connectomic ...
Ying Luan +19 more
wiley +1 more source
Regulation of Amyloid Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex [PDF]
, 2016 The prion protein (PrPC) has been suggested to operate as a scaffold/receptor protein in neurons, participating in both physiological and pathological associated events. PrPC, laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protein complex
Beraldo, Flavio H. +13 more
core +2 more sources
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]
, 2017 Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun +5 more
core +1 more source