Results 131 to 140 of about 20,152 (283)

Synaptic Depotentiation and mGluR5 Activity in the Nucleus Accumbens Drive Cocaine-Primed Reinstatement of Place Preference

Journal of Neuroscience, 2019
Understanding the neurobiological processes that incite drug craving and drive relapse has the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for reward and motivated behavior, in part due to alterations in ...
M. Benneyworth, Matthew C. Hearing, Anders J. Asp, A. Madayag, Anna E. Ingebretson, Clare E. Schmidt, Keelia A. Silvis, Erin B. Larson, S. Ebner, Mark J. Thomas   +9 more
semanticscholar   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla, Carmen Nanclares, Sara Expósito, Grace Gall, Paulo Kofuji, Alfonso Araque, Eduardo D. Martín, Rosario Moratalla   +7 more
wiley   +1 more source

Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders

Chronic Stress, 2023
Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence.
Stephen R. Baldassarri, Ruth H. Asch, Ansel T. Hillmer, Robert H. Pietrzak, Nicole DellaGioia, Irina Esterlis, Margaret T. Davis   +6 more
doaj   +1 more source

The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex [PDF]

, 2017
Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronociceptive behavior in healthy and monoarthritic rats.
Pereira, Ana Carla David, Sagalajev, Boriss, Wei, Hong, Almeida, Armando, Pertovaara, Antti, Pinto-Ribeiro, Filipa   +5 more
core   +3 more sources

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal

The Journal of Headache and Pain, 2020
Background The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization.
Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou, Lixue Chen   +8 more
doaj   +1 more source

A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization [PDF]

, 2013
SummarySynaptic plasticity induced by cocaine and other drugs underlies addiction. Here we elucidate molecular events at synapses that cause this plasticity and the resulting behavioral response to cocaine in mice.
Datko, Michael C., Domingo, Racquel D., Etzkorn, Felicia A., Hu, Jia-Hua, Kern, Dorothee, Linden, David J., Milshteyn, Aleksandr, Moore, Chester G., Park, Joo Min, Park, Sungjin, Reyes, Cindy M., Szumlinski, Karen K., Wang, Xiaodong J., Worley, Paul F., Xiao, Bo, Zhang, Ping-Wu   +15 more
core   +1 more source

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]

, 2011
Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey, Asrari, Barthel, Bègue-Kirn, Cabrera, Camargo, Doug Lobner, Duailibi, D’Souza, Fogal, Franco, Furey, Goldberg, Gronthos, Hansen, Hu, Kalyva, Katherine Pauly, Kaur, Keelan, Kim, Kim, Kymberly Fritz, Lobner, Lovschall, Marcato, Nie, Onishi, Pacheco, Paranjpe, Piani, Piattelli, Ricketts, Rutherford, Stanley, Stockton, Tziafas, Tziafas, Ward, Wood   +39 more
core   +2 more sources

Alterations in sleep, sleep spindle, and EEG power in mGluR5 knockout mice.

Journal of Neurophysiology, 2019
The type-5 metabotropic glutamate receptor (mGluR5) represents a novel therapeutic target for schizophrenia and other disorders. Schizophrenia is associated with progressive abnormalities in cortical oscillatory processes including reduced spindles (8 ...
David D. Aguilar, R. Strecker, R. Basheer, J. McNally   +3 more
semanticscholar   +1 more source

Clinical, Electroencephalogram and Imaging Characteristics of Patients With Anti‐LGI1 Antibody Encephalitis: A Multicenter Cohort Study

CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
To summarize and analyze the general clinical manifestations, laboratory tests, electroencephalography and imaging characteristics, treatment and prognosis of 88 patients with anti‐leucine‐rich glioma inactivated protein 1 antibody encephalitis (LGI1‐AE) at baseline, discharge, and follow‐up in China, aiming to identify risk factors affecting disease ...
Yang Zhao, Yue Yuan, Rong‐Ze Wang, Mei Cui, Shu‐Fen Chen, Ke‐Liang Chen, Meng‐Meng Li, Yu‐Yuan Huang, Hai‐Ning Zhang, Yan Zhang, Meng Zhao, Hui Tian, Li Sun, Jin‐Tai Yu   +13 more
wiley   +1 more source