The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology [PDF]
, 2005 Ritsuko Fujii +8 more
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Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice [PDF]
, 2019 Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Carlin, Dan +6 more
core +1 more source
NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin [PDF]
, 2005 Sudar Alagarsamy +5 more
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, 2014 Fragile X Syndrome (FXS) is a genetic disease due to a CGG trinucleotide expansion, named full mutation (greater than 200 CGG repeats), in the fragile X mental retardation 1 gene locus Xq27.3; which leads to an hypermethylated region in the gene promoter
Ayala-Zapata, Sebastián +5 more
core +1 more source
Using DREADD to Examine the Role of Infralimbic Gq-coupled Receptors in Fear Acquisition
, 2019 Post-Traumatic Stress Disorder (PTSD) can develop after a person experiences a very traumatic event that produces a strong and long-lasting aversive memory. During any given year, approximately 8 million adults will suffer from PTSD.
Haddock Martínez, Héctor A. +2 more
core
Metabotropic Glutamate 5 Receptor (mGluR5) Antagonists Decrease Nicotine Seeking, But Do Not Affect the Reinforcement Enhancing Effects of Nicotine [PDF]
, 2007 Matthew I. Palmatier +4 more
openalex +1 more source
Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold [PDF]
, 2008 Sameer Sharma +3 more
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Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates [PDF]
, 2008 Rosario Sánchez‐Pernaute +7 more
openalex +1 more source
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
core +1 more source