Results 141 to 150 of about 20,152 (283)
Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]
, 2010 Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
core +2 more sources
Molecular Brain, 2019 Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility.
Jisoo Lim +9 more
semanticscholar +1 more source
Journal of Neurochemistry, Volume 169, Issue 4, April 2025.This study examines how breast cancer and psychological stress impact the hippocampal proteome, uncovering altered signalling pathways linked to mitochondrial dysfunction, impaired energy production, and altered synaptic plasticity; that is, cellular processes that are critical for memory formation and cognitive health.
Myrthe Mampay +6 more
wiley +1 more source
The Journal of comparative neurology, 2019 Stimulation of the postsynaptic metabotropic glutamate receptor mGluR5 triggers retrograde signaling of endocannabinoids that activate presynaptic cannabinoid CB1 receptors on juxtaposing axon terminals.
Megan L. Fitzgerald +2 more
semanticscholar +1 more source
Neuropathology and Applied Neurobiology, Volume 51, Issue 2, April 2025.Alterations in glutamatergic receptors (GluK2), GABA transporter 1 (GAT1) and Lyn kinase (pLyn) in astrocytes, and glutamate receptors (pGluN2B) and Src kinase (pSrc) in microglia, may lead to hyperexcitability in Lafora disease (LD) mice. ABSTRACT Aims Lafora disease (LD; OMIM#254780) is a rare form of progressive myoclonus epilepsy characterised by ...
Rosa Viana +3 more
wiley +1 more source
Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα [PDF]
, 2014 The metabotropic glutamate receptor 5 (mGluR5) is a GPCR coupled to the heterotrimeric G protein Gaq/11 and activates signaling pathways important for excitatory synaptic transmission.
Raka, Fitore
core +1 more source
mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior
Neuropsychopharmacology, 2023 Xin Li +9 more
semanticscholar +1 more source
Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain [PDF]
, 2012 Painful bladder syndrome is a debilitating condition that affects 3–6% of women in the United States. Multiple lines of evidence suggest that changes in central nervous system processing are key to the development of chronic bladder pain conditions, but ...
Bruchas, Michael R +6 more
core +2 more sources
Translational Psychiatry, 2019 LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and ...
C. H. Chong +8 more
semanticscholar +1 more source
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.
PLoS Pathogens, 2017 Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrPC is required for toxicity, suggesting the existence of deleterious PrPC-dependent signaling cascades.
Despoina Goniotaki +10 more
doaj +1 more source