Cell Reports, 2015 Abnormal metabotropic glutamate receptor 5 (mGluR5) function, as a result of disrupted scaffolding with its binding partner Homer, contributes to the pathophysiology of fragile X syndrome, a common inherited form of intellectual disability and autism ...
Weirui Guo +4 more
doaj +1 more source
The prion protein constitutively controls neuronal store-operated ca2+ entry through Fyn Kinase [PDF]
, 2015 The prion protein (PrPC) is a cell surface glycoprotein mainly expressed in neurons, whose misfolded isoforms generate the prion responsible for incurable neurodegenerative disorders.
Agnese eDe Mario +8 more
core +4 more sources
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET
NeuroImage, 2021 Objective: Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability.
Adam P. Mecca +15 more
doaj
Early intervention combined with targeted treatment promotes cognitive and behavioral improvements in young children with fragile x syndrome. [PDF]
, 2012 Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Borodyanskara, Mariya +3 more
core +3 more sources
Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5 [PDF]
, 1998 Zhengping Jia +7 more
openalex +1 more source
Urine Trouble: A Molecular and Anatomical Examination of Bladder Pain [PDF]
, 2013 Interstitial cystitis or painful bladder syndrome (IC/PBS) is a chronic pain syndrome affecting 3-6% of women in the US. Some evidence suggests urothelial injury may cause some cases of IC/PBS.
Crock, Lara Wiley
core +1 more source
Differential Subcellular Localization of mGluR1a and mGluR5 in the Rat and Monkey Substantia Nigra [PDF]
, 2001 George W. Hubert +2 more
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Journal of Neuroscience, 2018 Astrocyte expression of metabotropic glutamate receptor 5 (mGluR5) is consistently observed in resected tissue from patients with epilepsy and is equally prevalent in animal models of epilepsy.
Anthony D. Umpierre +3 more
semanticscholar +1 more source
p11 regulates the surface localization of mGluR5 [PDF]
Molecular Psychiatry, 2015 Bushra Amreen +11 more
openaire +3 more sources
Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons [PDF]
, 2003 Suhas A. Kotecha +5 more
openalex +1 more source