Results 231 to 240 of about 20,586 (243)

mGluR5–PLCβ4–PKCβ2/PKCγ pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice

Epilepsy Research, 2008
While it is generally accepted that phospholipase C (PLC) and protein kinase C (PKC) are down-stream proteins involved in metabotropic glutamate receptor 5 (mGluR5)-related signal transduction, we still do not know which subtype of PLC or PKC is specifically regulated after mGluR5 activation.
Liu, J.X., Tang, Y.C., Liu, Y., Tang, F.R.   +3 more
openaire   +2 more sources

Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)

Bioorganic & Medicinal Chemistry Letters, 2005
Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)'s as low as around 100 nM were achieved.
Tasler S, Kraus M, Pegoraro S, Aschenbrenner A, Poggesi E, Testa R, MOTTA, Gaetano, Leonardi A.   +7 more
openaire   +3 more sources

Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia

Neurology, 2014
In 1982, Dr. Ian Carr described personality changes and memory loss in his 15-year-old daughter, who had limbic encephalitis and Hodgkin lymphoma (HL).1 He assumed “a circulating neurotransmitter-like molecule produced by the neoplasm” causing the brain disease, and noted that it “may be reversible and can be remembered as the Ophelia syndrome.” Almost
Prüss, Harald, Rothkirch, Marcus, Kopp, Ute, Hamer, Hajo M, Hagge, Mareike, Sterzer, Phillipp, Saschenbrecker, Sandra, Stöcker, Winfried, Harms, Lutz, Endres, Matthias   +9 more
openaire   +3 more sources

Inhibition of human hepatic CYP isoforms by mGluR5 antagonists

Life Sciences, 2004
Characterization of new chemical entities for their potential to produce drug-drug interactions is an important aspect of early drug discovery screening. In the present study, the potential for three metabotropic glutamate receptor antagonists to interact with recombinant human CYPs was investigated.
Mitchell D, Green, Xiaohui, Jiang, Christopher D, King   +2 more
openaire   +2 more sources

LRRC7 regulates neurite morphogenesis through mGluR5

2017
LRRC7 (Leucine-rich repeat containing 7) encodes for Densin-180, a scaffold protein in the postsynaptic density. LRRC7 has been reported as a risk allele for childhood emotional dysregulation and autism spectrum disorder. Knockout mice were reported to have defects related to metal illnesses and abnormal dendritic spine development.
Chong, CH, Ng, CP, Mak, HS, Li, Q, McAlonan, GM, Chan, SY   +5 more
openaire   +1 more source

mGluR5 positive allosteric modulators

Drugs of the Future, 2008
null Chen, Y., null Conn, P.J.
openaire   +1 more source

mGluR5

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

Cocaine Addiction and mGluR5

2017
K. Smart, S.G. Scala, S. El Mestikawy, C. Benkelfat, M. Leyton   +4 more
openaire   +1 more source

Role of mGluR5 in bladder pain

The Journal of Pain, 2012
L. Crock, B. Kolber, C. Morgan, S. Vogt, H. Lai, M. Bruchas, R. Gereau   +6 more
openaire   +1 more source

mGluR5 antagonists: discovery, characterization and drug development.

Current opinion in drug discovery & development, 2008
Disturbances of glutamate-mediated neurotransmission have been implicated in a broad range of nervous system disorders. Numerous attempts to correct nervous system dysfunction by pharmacological intervention at glutamate receptors have been made, and some of the approaches have achieved a high level of preclinical validation.
Fabrizio, Gasparini, Graeme, Bilbe, Baltazar, Gomez-Mancilla, Will, Spooren   +3 more
openaire   +1 more source