Results 251 to 260 of about 20,152 (283)

Astrocytic mGluR5 and the tripartite synapse

Neuroscience, 2016
In the brain, astrocytes occupy a key position between vessels and synapses. Among their numerous functions, these glial cells are key partners of neurons during synaptic transmission. Astrocytes detect transmitter release through receptors and transporters at the level of their processes, which are in close proximity to the tow neuronal elements of ...
Richard Robitaille, Aude Panatier, Aude Panatier   +2 more
openaire   +3 more sources

Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner

Science Signaling, 2020
A sex-specific prion-amyloid interaction predicts that some Alzheimer’s disease therapies may not work in female patients. Men only for an Alzheimer’s drug target β-Amyloid (Aβ) deposits in the brain contribute to the progression of Alzheimer’s disease ...
Khaled S. Abd-Elrahman, Awatif B Albaker, Jéssica M. de Souza, F. Ribeiro, M. Schlossmacher, M. Tiberi, A. Hamilton, S. Ferguson   +7 more
semanticscholar   +1 more source

NMDA-induced phosphorylation and regulation of mGluR5

Pharmacology Biochemistry and Behavior, 2002
Glutamate regulates neuronal function by acting on ionotropic receptors such as the N-methyl-D-aspartate (NMDA) receptor and metabotropic receptors (mGluRs). We have previously shown that low concentrations of NMDA are able to significantly potentiate mGluR5 responses via activation of a protein phosphatase and reversal of phosphorylation-induced ...
David A. Gutman, Candace Junge, P. Jeffrey Conn, Sudar Alagarsamy, Susan T. Rouse, Yoland Smith, George W. Hubert   +6 more
openaire   +2 more sources

Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia via attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription.

Pain, 2020
Mixed lineage leukemia 1 (MLL1)-mediated histone H3 lysine 4 trimethylation (H3K4me3) of a subset of genes has been linked to the transcriptional activation critical for synaptic plasticity, but its potential contribution to neuropathic allodynia ...
Tzer-Bin Lin, C. Lai, M. Hsieh, Y. Ho, Hsueh-Hsiao Wang, Po-Sheng Yang, Jen-Kun Cheng, Gin-Den Chen, Soo-Cheen Ng, H. Peng   +9 more
semanticscholar   +1 more source

Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia [PDF]

Neurology, 2014
In 1982, Dr. Ian Carr described personality changes and memory loss in his 15-year-old daughter, who had limbic encephalitis and Hodgkin lymphoma (HL).1 He assumed “a circulating neurotransmitter-like molecule produced by the neoplasm” causing the brain disease, and noted that it “may be reversible and can be remembered as the Ophelia syndrome.” Almost
Prüss, Harald, Rothkirch, Marcus, Kopp, Ute, Hamer, Hajo M, Hagge, Mareike, Sterzer, Phillipp, Saschenbrecker, Sandra, Stöcker, Winfried, Harms, Lutz, Endres, Matthias   +9 more
openaire   +3 more sources

Differential expression of mGluR5 in human lumbosacral motoneurons

NeuroReport, 2004
Glutamatergic excitotoxicity is one of the main hypotheses to explain motoneuronal degeneration in amyotrophic lateral sclerosis (ALS). Interestingly, autonomic motoneurons remain almost unaffected, even in late stages of the disease. Since glutamate receptors may mediate neurotoxic as well as neuroprotective effects, different expression patterns may ...
Johanna Anneser, Paul G. Ince, Gian Domenico Borasio, Pamela J. Shaw   +3 more
openaire   +3 more sources

Repeated nicotine exposure increases the intracellular interaction between ERK‐mGluR5 in the nucleus accumbens more in adult than adolescent rats

Addiction Biology, 2020
Intracellular interactions between protein kinases and metabotropic receptors in the striatum regulate behavioral changes in response to drug exposure.
Ju Hwan Yang, Sumin Sohn, Sunghyun Kim, Jieun Kim, J. Oh, In Soo Ryu, B. S. Go, E. Choe   +7 more
semanticscholar   +1 more source

Structure–activity relationship of thiopyrimidines as mGluR5 antagonists

Bioorganic & Medicinal Chemistry Letters, 2006
Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.
Krister Österlund, David Wensbo, Jonas Malmström, Alexander Minidis, Jan P. Mattsson, Martin Johansson, Lance G. Hammerland, Karolina Nilsson, Alecia Peterson, Andreas Wållberg   +9 more
openaire   +3 more sources