Results 271 to 280 of about 20,152 (283)

Distribution of mGluR1α and mGluR5 immunolabeling in primate prefrontal cortex

Journal of Comparative Neurology, 2003
AbstractMetabotropic glutamate receptors (mGluRs) mediate important modulatory glutamatergic influences throughout the brain. However, the specific localization and functions of group I mGluR subtypes (mGluR1α and mGluR5) in cortical neurotransmission are not well known, particularly in primates. To address this issue, we used immunoelectron microscopy
Yoland Smith, Yoland Smith, E. Chris Muly, E. Chris Muly, Marcelia Maddox   +4 more
openaire   +3 more sources

A Role for mGluR5 Receptors in Intravenous Methamphetamine Self‐Administration

Annals of the New York Academy of Sciences, 2008
Selective antagonists of the mGluR5 receptor attenuate rewarding and reinforcing effects of various drugs of abuse, including alcohol, nicotine, and cocaine. However, the ability of mGluR5 antagonists to alter the reinforcing effects of methamphetamine has not yet been explored. In this study, male Sprague‐Dawley rats were trained to perform an operant
Megan P. H. Osborne, M. Foster Olive
openaire   +3 more sources

Structural and molecular determinants regulating mGluR5 surface expression

Neuropharmacology, 2017
Trafficking of G protein-coupled receptors (GPCRs) to the plasma membrane is a pivotal process to fulfill their biological functions. Metabotropic glutamate receptors (mGluRs; mGluR1-8) are expressed throughout the CNS and are important for modulating synaptic transmission and plasticity.
Kai Chang, Katherine W. Roche
openaire   +2 more sources

In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand

Life Sciences, 2003
We have characterized the in vitro properties of 3-[3H]methoxy-5-(pyridin-2-ylethynyl)pyridine ([3H]MethoxyPyEP), an analogue of the mGluR(5) receptor subtype antagonist MPEP [2-methyl-6-(phenylethynyl)-pyridine], in rat tissue preparations using tissue homogenates and autoradiography. Binding of [3H]MethoxyPyEP to rat cortex, hippocampus, thalamus and
Donald Burns, Terence G. Hamill, Stephen Krause, Ashok Chaudhary, Shil Patel, Raymond A. Gibson   +5 more
openaire   +3 more sources

mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress

Molecular Neurobiology, 2021
Xiaotao Xu, Kaixuan Wu, Xiaqing Ma, Wenying Wang, Haiyan Wang, Min Huang, Limin Luo, Chen Su, Tifei Yuan, Haibo Shi, Ji Han, Aizhong Wang, Tao Xu   +12 more
semanticscholar   +1 more source

mGluR5 positive allosteric modulators

Drugs of the Future, 2008
P.J. Conn, Yelin Chen
openaire   +2 more sources

Role of mGluR5 in bladder pain

The Journal of Pain, 2012
Benedict J. Kolber, H. Henry Lai, Lara W. Crock, Clinton D. Morgan, Michael R. Bruchas, Robert W. Gereau, Sherri K. Vogt   +6 more
openaire   +2 more sources

Developmental and molecular studies of mGluR5

Neuropharmacology, 1996
Carmelo Romano, John W. Olney, Karen L. O'Malley, Nigel W. Daw, Silvia Reid   +4 more
openaire   +2 more sources

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

Nature Neuroscience, 2017
Diana G. Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, V. Batalha, J. Coelho, Eva M Szegö, Inês Marques-Morgado, S. Vaz, J. Rhee, M. Schmitz, I. Zerr, Luísa V. Lopes, T. Outeiro   +12 more
semanticscholar   +1 more source

Cocaine Addiction and mGluR5

2017
K. Smart, S.G. Scala, S. El Mestikawy, C. Benkelfat, M. Leyton   +4 more
openaire   +1 more source