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MHC-NP: Predicting peptides naturally processed by the MHC
Journal of Immunological Methods, 2013We present MHC-NP, a tool for predicting peptides naturally processed by the MHC pathway. The method was part of the 2nd Machine Learning Competition in Immunology and yielded state-of-the-art accuracy for the prediction of peptides eluted from human HLA-A*02:01, HLA-B*07:02, HLA-B*35:01, HLA-B*44:03, HLA-B*53:01, HLA-B*57:01 and mouse H2-D(b) and H2-K(
Sébastien, Giguère +5 more
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Odortypes and MHC peptides: complementary chemosignals of MHC haplotype?
Trends in Neurosciences, 2006The olfactory and immune systems must perform optimally in the task of recognizing thousands of molecules to ensure survival. A particularly intriguing link between these systems is that animals can smell differences in the major histocompatibility complex (MHC), a cluster of highly polymorphic genes found on human chromosome 6 and mouse chromosome 17.
Diego, Restrepo +4 more
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2012
Ubiquitinated protein detection is often troublesome since in most cases this modification reduces the half-life of targeted proteins, inducing their degradation. Furthermore, ubiquitination is reversible thanks to the action of highly specific deubiquitinases present in all eukaryotic cells.
Aude, De Gassart +2 more
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Ubiquitinated protein detection is often troublesome since in most cases this modification reduces the half-life of targeted proteins, inducing their degradation. Furthermore, ubiquitination is reversible thanks to the action of highly specific deubiquitinases present in all eukaryotic cells.
Aude, De Gassart +2 more
openaire +2 more sources
MHC-associated and MHC-independent urinary chemosignals in mice
Physiology & Behavior, 1996The chemosensory identity of mice, rats, and humans is determined partly by polymorphic genes of the major histocompatibility complex (MHC). In inbred strains of mice as well as in seminatural populations MHC-associated mating preferences selectively influence reproductive success.
F, Eggert +4 more
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MHC and MHC‐related proteins as pleiotropic signal molecules
The FASEB Journal, 2002ABSTRACT Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC‐related molecules have a much more varied function in the ...
David M, Ojcius +3 more
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1998
Abstract MHC2: A Practical Approach offers a comprehensive and accessible guide to the fast-growing and fascinating field of MHC research. This companion volume to MHC1 covers topics including: generation of HLA-specific human monoclonal antibodies; sequencing of proteins; assembly of MHC molecules; expression, purification, and ...
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Abstract MHC2: A Practical Approach offers a comprehensive and accessible guide to the fast-growing and fascinating field of MHC research. This companion volume to MHC1 covers topics including: generation of HLA-specific human monoclonal antibodies; sequencing of proteins; assembly of MHC molecules; expression, purification, and ...
openaire +1 more source