Results 211 to 220 of about 551,654 (347)

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Nature Immunology, 2017
Amira A. Barkal, K. Weiskopf, Kevin S. Kao, S. Gordon, B. Rosental, Y. Y. Yiu, B. George, Maxim Markovic, N. G. Ring, Jonathan M. Tsai, K. McKenna, P. Ho, Robin Z. Cheng, James Y Chen, Layla J. Barkal, A. Ring, I. Weissman, R. Maute   +17 more
semanticscholar   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Structural Design of T-Cell Epitope-Based mRNA Vaccine Constructs Determines the Quality of T-Cell Immunity and Protective Efficacy Against SARS-CoV-2 in Mice. [PDF]

Vaccines (Basel)
Gushchin VA, Siniavin AE, Pochtovyi AA, Dzharullaeva AS, Shcherbinin DN, Ungur AS, Tukhvatulin AI, Shuliakova IV, Kleymenov DA, Mazunina EP, Bykonia EN, Kozlova SR, Usachev EV, Zorkov ID, Grousova DM, Iliukhina AA, Gintsburg AL, Logunov DY.   +17 more
europepmc   +1 more source

Evaluating the psychometric properties of the Mental Health Continuum-Short Form (MHC-SF).

Journal of Clinical Psychology, 2011
S. Lamers, G. Westerhof, E. Bohlmeijer, P. T. ten Klooster, Corey Keyes   +4 more
semanticscholar   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Non-cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC-E Restricted CD8 T Cell Population. [PDF]

Eur J Immunol
Yang X, Colden MA, Coombs R, Arana K, Tran D, Valerio MM, Robey EA, Coscoy L.   +7 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

TEpiNom: A computational framework integrating population data to prioritize Plasmodium falciparum T cell epitopes. [PDF]

Vaccine
Laurenson AJ, Pierce BG, Takala-Harrison S, Laurens MB.   +3 more
europepmc   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

Nature, 2015
S. Kreiter, M. Vormehr, Niels van de Roemer, M. Diken, M. Löwer, Jan Diekmann, Sebastian Boegel, Barbara Schroers, F. Vascotto, J. Castle, A. Tadmor, S. Schoenberger, C. Huber, Ö. Türeci, U. Şahin   +14 more
semanticscholar   +1 more source