Results 231 to 240 of about 551,654 (347)

The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.

Annual Review of Immunology, 2017
Freidrich M Cruz, Jeff D. Colbert, Elena Merino, B. Kriegsman, K. Rock   +4 more
semanticscholar   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer. [PDF]

Front Med (Lausanne)
Runtunuwu SVBE, Tallei TE, Kim HJ, Park MN, Celik I, Kirilmaz B, Turalaki GLA, Fatimawali F, Tendean LEN, Kaseke MM, Makawaehe DR, Rambi EV, Kim B.   +12 more
europepmc   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Extraordinary diversity of antiviral immune-related gene families across 38 bat species. [PDF]

BMC Biol
Liu G, Ren Y, Zhou S, Hua Q, Chen P, Zhang H, Liu Z.   +6 more
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion. [PDF]

Proc Natl Acad Sci U S A
Khalil MI, Wang J, Vu L, Yang C, Yin C, Chadha S, Nabors H, Vocelle D, May DG, Chrisopulos RJ, Welbon CC, Zhou L, Roux KJ, Spanos WC, Bernard MP, Mi QS, Pyeon D.   +16 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Immunopeptidomics of cutaneous leishmaniasis patients reveals the natural antigenic landscape. [PDF]

Front Immunol
de Vrij N, Pepermans E, Laurijssen L, Pham TT, Thijs L, Boonen K, Ramadan K, Maes I, Aleka Y, Kassa M, Mekonnen T, Asres MS, Woldetensay M, Hassen S, Bialfew F, Tilahun Zewdu F, Abdela SG, Domagalska MA, Cuypers B, van Henten S, van Griensven J, Meysman P, Baggerman G, Laukens K, Adriaensen W.   +24 more
europepmc   +1 more source