Results 141 to 150 of about 620,907 (297)

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

open access: yesChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo   +4 more
wiley   +1 more source

Point-of-Care CagA Antibody Positivity and Its Association with Precancerous Gastric Changes. [PDF]

open access: yesCancer Prev Res (Phila)
Kumar S   +9 more
europepmc   +1 more source

Weathering the storms of climate change: Preparing persons with disabilities and the physiatrists who provide their care for extreme hurricanes

open access: yesPM&R, EarlyView.
Abstract Climate‐driven disasters have disproportionate and often devastating consequences on individuals with disabilities. Warming ocean and air temperatures are fueling more extreme tropical cyclones, further endangering those living in at‐risk regions.
Mollie Andreae   +4 more
wiley   +1 more source

The stratospheric gravity wave field produced by a supercell

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Supercells are a class of long‐lasting thunderstorms with rotating updrafts that often cause severe weather, hail, and tornadoes. This study uses numerical simulations to characterize the stratospheric gravity waves that are caused by these storms.
David S. Nolan, Yi Dai
wiley   +1 more source

An objective Bayesian method for including parameter uncertainty in ensemble model output statistics

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Conventional model output statistics and ensemble model output statistics methods for calibrating ensemble forecasts lead to severe underestimation of the probabilities of ensemble extremes (in blue). This is because they ignore statistical parameter uncertainty.
Stephen Jewson   +4 more
wiley   +1 more source

The Association Between Cannabis Use and Electrocardiographic Abnormalities in People Living With HIV. [PDF]

open access: yesJ Acquir Immune Defic Syndr
Larson ME   +27 more
europepmc   +1 more source

Bias in Peak Flood Discharges: Are Our Bridges and Culverts Undersized?

open access: yesRiver Research and Applications, EarlyView.
ABSTRACT Reliable methods for peak discharge predictions at ungaged locations are required for infrastructure design and floodplain management. For decades, a standard practice in the United States has been to utilize US Geological Survey regional regression equations (StreamStats) as a singular method. However, implementation of multiple methods, such
Steven E. Yochum, Tyler Wible
wiley   +1 more source

Correction: Drug use and sexual behaviors among women who inject drugs and use a syringe services program; Miami, Florida. [PDF]

open access: yesHarm Reduct J
Hervera B   +12 more
europepmc   +1 more source

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