Results 1 to 10 of about 14,868 (228)

Cardiac 123I-MIBG Scintigraphy in Neurodegenerative Parkinson Syndromes: Performance and Pitfalls in Clinical Practice [PDF]

Frontiers in Neurology, 2019
Purpose: Cardiac [123I]metaiodobenzylguanidine scintigraphy (123I-MIBG), reflecting postganglionic cardiac autonomic denervation, is proposed for early detection of Parkinson's disease (PD; reduced tracer uptake) and separation from Multiple System ...
Cornelia Skowronek, Cornelia Skowronek, Leonora Zange, Leonora Zange, Axel Lipp, Axel Lipp   +5 more
doaj   +5 more sources

Comparison of High-Specific-Activity Ultratrace 123/131 I-MIBG and Carrier-Added 123/131 I-MIBG on Efficacy, Pharmacokinetics, and Tissue Distribution [PDF]

Cancer Biotherapy and Radiopharmaceuticals, 2010
Metaiodobenzylguanidine (MIBG) is an enzymatically stable synthetic analog of norepinephrine that when radiolabled with diagnostic ((123)I) or therapeutic ((131)I) isotopes has been shown to concentrate highly in sympathetically innervated tissues such ...
Marie Boyd, John W Babich
exaly   +2 more sources

Experimental study on the treatment of norepinephrine transporter-overexpressing pheochromocytomas and paragangliomas: a synthetic lethality strategy combining 131I-MIBG with PARP inhibitors [PDF]

Frontiers in Oncology
IntroductionPheochromocytomas and paragangliomas (PPGLs) are associated with poor prognosis especially in patients with metastatic spread. This study aims to investigate the therapeutic potential of 131I-MIBG and the PARP inhibitor fluzoparib ...
Jieping Song, Lulu Zhang, Fan Qiu, Xiumin Shi, Rui Tian, Chuan Zhang, Xiaoyuan Li, Feng Wang   +7 more
doaj   +2 more sources

A case of adrenal endothelial cyst (vascular type) with positive 123I-MIBG uptake [PDF]

Urology Case Reports
123I-metaiodobenzylguanidine (MIBG) scintigraphy is highly accurate for diagnosing pheochromocytoma and paraganglioma (PPGL), and positive uptake in non-PPGL adrenal lesions is rare.
Riona Asai, Tomonori Sato, Yuto Yamazaki, Yuta Tezuka, Yoshikiyo Ono, Hiromichi Katayama, Yohei Satake, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Hideki Katagiri, Akihiro Ito   +11 more
doaj   +2 more sources

Metastatic Pheochromocytoma Diagnosed with 131I-MIBG SPECT/CT Imaging in a Patient with Pathogenic VHL Mutation

World Journal of Nuclear Medicine, 2022
Pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor arising from chromaffin cells of adrenal medulla with approximate prevalence of 0.1 to 0.6% in patients suffering from hypertension.
Kousik Vankadari, Raman Boddula, Aditya Gajanan Hegde, Chimutai Chinte   +3 more
doaj   +1 more source

Thyroid [123I]MIBG uptake in Parkinson’s disease and diabetes mellitus

IBRO Neuroscience Reports, 2023
Thyroid [123I]MIBG uptake is proposed as a tool for differentiating between Parkinson’s disease (PD) and diabetes mellitus (DM) on [123I]MIBG scintigraphies since both patient groups show decreased cardiac uptake.
Tatyana D. Fedorova, Karoline Knudsen, Thorsten K. Rasmussen, Jacob Horsager, Adjmal Nahimi, Casper Skjærbæk, Eva Schaeffer, Daniela Berg, Astrid J. Terkelsen, Per Borghammer   +9 more
doaj   +1 more source

Establishment of Quality Standard for Metaiodobenzylguanidine as Radiopharmaceutical Precursor

Journal of Isotopes, 2023
Meta-iodobenzylguanidine (MIBG) is used as a chemical precursor of radioiodinated (123I or 131I) MIBG preparation. In order to control the quality of MIBG, in this study, Infrared identification of self-made MIBG was carried out, the physical and ...
CHEN Mengyi;DONG Ruilin;XING Yu;ZHOU Jiajun;QIU Shanshan;SUN Mingyue;WANG Xiaoming;WU Fuhai;HU Ji
doaj   +1 more source

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

EJNMMI Research, 2021
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia.
Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

EJNMMI Research, 2020
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia.
Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B. P. van Kuilenburg, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

Diagnostic Use of Post-therapy ¹³¹I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma

Diagnostics, 2020
123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy is used for evaluating disease extent in children with neuroblastoma. 131I-mIBG therapy has been used for evaluation in children with high-risk neuroblastoma, and post-therapy 131I-mIBG scintigraphy ...
Hiroshi Wakabayashi, Daiki Kayano, Anri Inaki, Raita Araki, Rie Kuroda, Norihito Akatani, Takafumi Yamase, Satoru Watanabe, Tomo Hiromasa, Yuji Kunita, Hiroshi Mori, Shintaro Saito, Yasuhiro Ikawa, Toshihiro Fujiki, Seigo Kinuya   +14 more
doaj   +1 more source