Results 11 to 20 of about 14,868 (228)

Two Cases of Hereditary Paraganglioma-Pheochromocytoma Syndrome in Siblings, Caused by a Novel Succinate Dehydrogenase Complex Subunit D Variant. [PDF]

IJU Case Rep
ABSTRACT Introduction Pheochromocytomas and paragangliomas are increasingly recognized as hereditary malignancies, with ~30%–40% of cases involving germline variants. We report a familial case of hereditary pheochromocytoma‐paraganglioma syndrome caused by a novel variant in the SDHD gene.
Nakamura R, Yamamoto Y, Kato T, Mukai K, Nomura M, Nojima S, Hatano K, Kakuta Y, Kawashima A, Nonomura N.   +9 more
europepmc   +2 more sources

High clinical diagnostic accuracy of combined salivary gland and myocardial metaiodobenzylguanidine scintigraphy in the diagnosis of Parkinson’s disease

Frontiers in Aging Neuroscience, 2023
BackgroundDecreased myocardial uptake of 131I-metaiodobenzylguanidine (MIBG) is known to be an important feature to diagnose Parkinson’s disease (PD). However, the diagnosis accuracy of myocardial MIBG scintigraphy alone is often unsatisfying.
Shuangfang Li, Shuangfang Li, Lei Yue, Shuzhen Chen, Zhuang Wu, Jingxing Zhang, Ronghua Hong, Ludi Xie, Kangwen Peng, Chenghong Wang, Ao Lin, Lingjing Jin, Lingjing Jin, Lingjing Jin, Qiang Guan   +14 more
doaj   +1 more source

The potential role of the cardiac MIBG scan in differentiating the drug-induced Parkinsonism from Parkinson’s disease

Clinical Parkinsonism & Related Disorders, 2022
Introduction: Considering the difficulties of differentiating Parkinson’s disease (PD) from drug-induced Parkinsonism (DIP) in patients receiving antipsychotics, developing robust diagnostic tools is essential. Herein, we used the metaiodobenzylguanidine
Mahan Shafie, Mahsa Mayeli, Samira Saeidi, Zahra Mirsepassi, Mehrshad Abbasi, Melika Shafeghat, Vajiheh Aghamollaii   +6 more
doaj   +1 more source

The relation between cardiac 123I-mIBG scintigraphy and functional response 1 year after CRT implantation [PDF]

, 2020
Cardiac resynchronization therapy (CRT) is a disease-modifying therapy in patients with chronic heart failure (CHF). Current guidelines ascribe CRT eligibility on three parameters only: left ventricular ejection fraction (LVEF), QRS duration, and New ...
de Groot, J R, De Vincentis, G, Frantellizzi, V, Gheysens, O, Nakajima, K, Poel, E, Verberne, H J, Verschure, D O   +7 more
core   +1 more source

CUDC-907, a dual PI3K/histone deacetylase inhibitor, increases meta-iodobenzylguanidine uptake (123/131I-mIBG) in vitro and in vivo: a promising candidate for advancing theranostics in neuroendocrine tumors

Journal of Translational Medicine, 2023
Background Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG), a norepinephrine analog taken ...
Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann, Karim Abid   +8 more
doaj   +1 more source

On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases. [PDF]

PLoS ONE, 2016
Abnormal cardiac uptake of 123I-metaiodobenzylguanidine (123I-MIBG) is a diagnostic marker of Lewy body diseases (LBDs), e.g., Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mori   +11 more
doaj   +1 more source

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter [PDF]

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
Babich, John W, Boyd, Marie, Champion, Sue, Gaze, Mark N, Mairs, Robert J, McCluskey, Anthony G, Pimlott, Sally L, Tesson, Mathias   +7 more
core   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitization of cancer cells [PDF]

, 2013
<p>Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome ...
Ballangrud, Børup, Cen, Cohen, Hald, Maris, Sullivan, Yu, Yuhas   +8 more
core   +1 more source

Natural History and Management of Familial Paraganglioma Syndrome Type 1: Long-Term Data from a Large Family [PDF]

, 2020
Head and neck paragangliomas are the most common clinical features of familial paraganglioma syndrome type 1 caused by succinate dehydrogenase complex subunit D (SDHD) mutation. The clinical management of this syndrome is still unclear.
Cantisani, Vito, Colao, Annamaria, Di Leo, Nicola, Faggiano, Antongiulio, Feola, Tiziana, Giannetta, Elisa, Isidori, Andrea M, Lenzi, Andrea, Modica, Roberta, Polti, Giorgia, Puliani, Giulia, Sesti, Franz, Verrico, Monica   +12 more
core   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitisation of cancer cells. [PDF]

, 2013
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity ...
Babich, John W, Boyd, Marie, Mairs, Robert J., Rae, Colin, Sorensen, Annette, Tesson, M.   +5 more
core   +1 more source