Results 171 to 180 of about 14,868 (228)

Polymer-supported radiopharmaceuticals: [131I]MIBG and [123I]MIBG

Journal of Labelled Compounds and Radiopharmaceuticals, 1999
A new method has been developed that produces no-carrier-added [131I]MIBG in ≥90% radiochemical yield and high chemical purity. Isolation and purification are simple involving just filtration and absorption and desorption onto a C18 Sep-Pak™ cartridge.
Duncan H. Hunter, Xizhen Zhu
openaire   +1 more source

False positive MIBG scan

Medical and Pediatric Oncology, 1997
The fortuitous discovery of a left posterior cervico-mediastinal mass during hospitalization for hemolytic anemia in an 18 month old baby is reported. Metaiodobenzylguanidine (MIBG) uptake suggested a sympathetic tissue origin of the mass despite negative catecholamines excretion, but histopathologic examination revealed a juvenile capillary angioma ...
D, Frappaz, F, Giammarile, P, Thiesse, D, Ranchere-Vince, D, Louis, L, Guibaud, G, Souillet, V, Combaret, M, Schell, C, Bergeron   +9 more
openaire   +2 more sources

Radiolabelled mIBG in the treatment of neuroblastoma

European Journal of Cancer, 1996
ALTHOUGH THE outlook for children with neuroblastoma has improved in recent decades following the introduction of aggressive multi-agent chemotherapy [ 11, the prognosis remains poor. This is especially true for patients over the age of 1 year, those with advanced disease at presentation and those with biological markers of unfavourable disease, such ...
M N, Gaze, T E, Wheldon
openaire   +2 more sources

MIBG in neuroblastoma diagnosis and treatment

Seminars in Pediatric Surgery, 2019
Neuroblastoma is a heterogenous disease, with solid tumors arising in the adrenal gland or paraspinal regions in young children. Neuroblastoma is unique, with varied presentation and prognosis based on primary location and tumor stage. Tumor behavior and response to treatment ranges from spontaneous regression to disseminated, lethal disease depending ...
Elizabeth, Olecki, Christa N, Grant
openaire   +2 more sources

Cerebral uptake of MIBG

Nuclear Medicine Communications, 1991
Radiolabelled metaiodobenzylguanidine (MIBG) localizes in adrenergic neurons. A study was carried out to evaluate the uptake of this radiopharmaceutical in cerebral tissues. Twenty-three patients with neural crest tumours, who had no evidence of central nervous system disease, were evaluated.
J, Bomanji, J, Moyes, A H, Huneidi, K, Solanki, L, Hawkins, C C, Nimmon, J E, Kingston, K E, Britton   +7 more
openaire   +2 more sources

Intraoperative Detection of Ganglioneuromas With 123I-MIBG

Clinical Nuclear Medicine, 2012
Radioactive MIBG can be used in radioguided surgery for neuroendocrine tumors. We report the case of a man with a mutation in the succinate dehydrogenase subunit B (SDHB) gene, in which an abdominal MRI scan identified two 5-mm left para-aortic nodules, suspect for paragangliomas. Subsequent SPECT revealed increased uptake of tracer.
Hulsteijn, L.T. van, Hiel, B. van der, Smit, J.W.A., Stokkel, M.P., Corssmit, E.P.   +4 more
openaire   +3 more sources

MIBG Uptake in Pancreas as a Normal Variant

Clinical Nuclear Medicine, 2021
Abstract A 5-year-old girl with high-risk neuroblastoma underwent 123I-MIBG scintigraphy for disease restaging. The whole-body images showed a faint MIBG uptake in the midabdomen. Abdominal SPECT/CT demonstrated the focus locating in the pancreatic head. However, this activity disappeared on delayed acquisition at 6-hour later. Follow-up MIBG
Yu, Wang, Xu, Yang, Wei, Wang, Jigang, Yang   +3 more
openaire   +2 more sources

Neuroendocrine Tumors (MIBG)

2008
Uptake of radiopharmaceuticals in the adrenal medulla was first demonstrated in 1967, using C-14-labeled epinephrine and precursors (Morales et al. 1967). In subsequent years this tracer was shown to depict neuroblastomas and pheochromocytomas (Lieberman et al. 1969; Anderson et al. 1973).
M. Welsch, F. Grünwald
openaire   +1 more source

Effects of anesthetic agents on cellular 123I-MIBG transport and in vivo 123I-MIBG biodistribution

European Journal of Nuclear Medicine and Molecular Imaging, 2007
Small animal imaging with meta-iodobenzylguanidine (MIBG) allows characterization of animal models, optimization of tumor treatment strategies, and monitoring of gene expression. Anesthetic agents, however, can affect norepinephrine (NE) transport and systemic sympathetic activity.
Bong-Ho, Ko, Jin-Young, Paik, Kyung-Ho, Jung, Jun-Sang, Bae, Eun Jung, Lee, Yearn Seong, Choe, Byung-Tae, Kim, Kyung-Han, Lee   +7 more
openaire   +2 more sources

[131I-MIBG-meta-iodobencylguanidine (131I-MIBG) in the study of neuroblastoma].

Anales espanoles de pediatria, 1987
Ten patients with neuroblastoma were scintigraphed with I131-meta-iodobenzylguanidine (MIBG). Lugol solution was previously administered orally to all patients in order to avoid uptake of radioactive iodide by the thyroid gland. The compound was injected intravenously, 0.5 mCi/1.73 m2 of body surface.
J, Ferris, O, Caballero, A, Verdeguer, C, Esquembre, V, Castel   +4 more
openaire   +1 more source