Results 11 to 20 of about 18,680 (257)

Synthesis, Radiochemical Characterization, and Biodistribution of a ¹⁸⁸Re Analogue of [¹³¹I]mIBG in a Neuroblastoma Xenograft Model. [PDF]

J Labelled Comp Radiopharm
A 188Re analogue of [131I]mIBG was synthesized in moderate yields using 188Re‐4 + 1 chemistry. In vitro studies using SK‐N‐SH neuroblastoma cell lines demonstrated that the compound exhibited affinity for norepinephrine transporters expressed on these cancer cells.
Sakhare N, Kumar D, Das S, Mitra A, Mirapurkar S, Rani G, Sheela M, Chirayil V, Mohanty B, Mathur A, Mallia MB, Chaudhari P.   +11 more
europepmc   +2 more sources

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

EJNMMI Research, 2021
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia.
Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

EJNMMI Research, 2020
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia.
Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B. P. van Kuilenburg, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

The relation between cardiac 123I-mIBG scintigraphy and functional response 1 year after CRT implantation [PDF]

, 2020
Cardiac resynchronization therapy (CRT) is a disease-modifying therapy in patients with chronic heart failure (CHF). Current guidelines ascribe CRT eligibility on three parameters only: left ventricular ejection fraction (LVEF), QRS duration, and New ...
de Groot, J R, De Vincentis, G, Frantellizzi, V, Gheysens, O, Nakajima, K, Poel, E, Verberne, H J, Verschure, D O   +7 more
core   +1 more source

Diagnostic Use of Post-therapy ¹³¹I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma

Diagnostics, 2020
123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy is used for evaluating disease extent in children with neuroblastoma. 131I-mIBG therapy has been used for evaluation in children with high-risk neuroblastoma, and post-therapy 131I-mIBG scintigraphy ...
Hiroshi Wakabayashi, Daiki Kayano, Anri Inaki, Raita Araki, Rie Kuroda, Norihito Akatani, Takafumi Yamase, Satoru Watanabe, Tomo Hiromasa, Yuji Kunita, Hiroshi Mori, Shintaro Saito, Yasuhiro Ikawa, Toshihiro Fujiki, Seigo Kinuya   +14 more
doaj   +1 more source

High clinical diagnostic accuracy of combined salivary gland and myocardial metaiodobenzylguanidine scintigraphy in the diagnosis of Parkinson’s disease

Frontiers in Aging Neuroscience, 2023
BackgroundDecreased myocardial uptake of 131I-metaiodobenzylguanidine (MIBG) is known to be an important feature to diagnose Parkinson’s disease (PD). However, the diagnosis accuracy of myocardial MIBG scintigraphy alone is often unsatisfying.
Shuangfang Li, Shuangfang Li, Lei Yue, Shuzhen Chen, Zhuang Wu, Jingxing Zhang, Ronghua Hong, Ludi Xie, Kangwen Peng, Chenghong Wang, Ao Lin, Lingjing Jin, Lingjing Jin, Lingjing Jin, Qiang Guan   +14 more
doaj   +1 more source

The potential role of the cardiac MIBG scan in differentiating the drug-induced Parkinsonism from Parkinson’s disease

Clinical Parkinsonism & Related Disorders, 2022
Introduction: Considering the difficulties of differentiating Parkinson’s disease (PD) from drug-induced Parkinsonism (DIP) in patients receiving antipsychotics, developing robust diagnostic tools is essential. Herein, we used the metaiodobenzylguanidine
Mahan Shafie, Mahsa Mayeli, Samira Saeidi, Zahra Mirsepassi, Mehrshad Abbasi, Melika Shafeghat, Vajiheh Aghamollaii   +6 more
doaj   +1 more source

CUDC-907, a dual PI3K/histone deacetylase inhibitor, increases meta-iodobenzylguanidine uptake (123/131I-mIBG) in vitro and in vivo: a promising candidate for advancing theranostics in neuroendocrine tumors

Journal of Translational Medicine, 2023
Background Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG), a norepinephrine analog taken ...
Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann, Karim Abid   +8 more
doaj   +1 more source

On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases. [PDF]

PLoS ONE, 2016
Abnormal cardiac uptake of 123I-metaiodobenzylguanidine (123I-MIBG) is a diagnostic marker of Lewy body diseases (LBDs), e.g., Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mori   +11 more
doaj   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitisation of cancer cells. [PDF]

, 2013
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity ...
Babich, John W, Boyd, Marie, Mairs, Robert J., Rae, Colin, Sorensen, Annette, Tesson, M.   +5 more
core   +1 more source