Results 51 to 60 of about 203,205 (263)

Therapy-induced modulation of tumor vasculature and oxygenation in a murine glioblastoma model quantified by deep learning-based feature extraction

Scientific Reports
Glioblastoma presents characteristically with an exuberant, poorly functional vasculature that causes malperfusion, hypoxia and necrosis. Despite limited clinical efficacy, anti-angiogenesis resulting in vascular normalization remains a promising ...
Nadine Bauer, Daniel Beckmann, Dirk Reinhardt, Nicole Frost, Stefanie Bobe, Raghu Erapaneedi, Benjamin Risse, Friedemann Kiefer   +7 more
doaj   +1 more source

Clinical application of Vitek-derived minimum inhibitory concentration values: Proof of concept study

Southern African Journal of Infectious Diseases, 2023
Background: Minimum inhibitory concentration (MIC) values are useful in guiding appropriate antimicrobial therapy however, routine provision and interpretation of MIC values to guide clinical decision-making is challenging.
Warren Lowman
doaj   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

CADRU GENERAL PENTRU FOLOSIREA TEHNICILOR DIN JOCURI VIDEO ÎN PROCESUL DE SCHIMBARE ORGANIZAŢIONALĂ

Studia Universitatis Moldaviae: Stiinte Sociale, 2016
În acest articol studiem felul în care tehnicile din jocuri video pot fi folosite în procesul de schimbare organizaţională din perspectiva comunicării organizaţionale, cu obiectivul de a eficientiza schimbarea şi de a integra în contextul orga­ni ...
Tudor MIC
doaj  

Visualising the Cardiovascular System of Embryos of Biomedical Model Organisms with High Resolution Episcopic Microscopy (HREM)

Journal of Cardiovascular Development and Disease, 2018
The article will briefly introduce the high-resolution episcopic microscopy (HREM) technique and will focus on its potential for researching cardiovascular development and remodelling in embryos of biomedical model organisms.
Wolfgang J. Weninger, Barbara Maurer-Gesek, Lukas F. Reissig, Fabrice Prin, Robert Wilson, Antonella Galli, David J. Adams, Jacqueline K. White, Timothy J. Mohun, Stefan H. Geyer   +9 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Blood supply of the human carotid body

Scientific Reports
Glomic arteries (GAs) supply the carotid body (CB), a chemosensory organ at the carotid bifurcation. Accurate knowledge of GA anatomy is essential for CB surgery and understanding the impact of carotid artery atherosclerosis on breathing and blood ...
Atieh Seyedian Moghaddam, Stefan H. Geyer, Berna Dogan, Paata Pruidze, Jeremias T. Weninger, Karoline M. Schwendt, Wolfgang J. Weninger   +6 more
doaj   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Metaphors in the Wisdom Literature of the Hebrew Bible and Contemporary Art

Religions, 2016
Biblical wisdom literature is a treasure-trove of powerful metaphors. This article presents a sample of these metaphors and their significant impact on contemporary artwork. The impact is characterized by both appropriation and adaptation, similitude and
Bálint Károly Zabán
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source