Results 61 to 70 of about 278,530 (314)

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Therapy-induced modulation of tumor vasculature and oxygenation in a murine glioblastoma model quantified by deep learning-based feature extraction

Scientific Reports
Glioblastoma presents characteristically with an exuberant, poorly functional vasculature that causes malperfusion, hypoxia and necrosis. Despite limited clinical efficacy, anti-angiogenesis resulting in vascular normalization remains a promising ...
Nadine Bauer, Daniel Beckmann, Dirk Reinhardt, Nicole Frost, Stefanie Bobe, Raghu Erapaneedi, Benjamin Risse, Friedemann Kiefer   +7 more
doaj   +1 more source

Using ROC curves to choose minimally important change thresholds when sensitivity and specificity are valued equally : the forgotten lesson of Pythagoras : theoretical considerations and an example application of change in health status [PDF]

, 2014
Background Receiver Operator Characteristic (ROC) curves are being used to identify Minimally Important Change (MIC) thresholds on scales that measure a change in health status. In quasi-continuous patient reported outcome measures, such as those that
Abel Gary, Abel, Gary, Robert Froud, Froud, Robert J., Gary Abel, Froud Robert   +5 more
core   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

CADRU GENERAL PENTRU FOLOSIREA TEHNICILOR DIN JOCURI VIDEO ÎN PROCESUL DE SCHIMBARE ORGANIZAŢIONALĂ

Studia Universitatis Moldaviae: Stiinte Sociale, 2016
În acest articol studiem felul în care tehnicile din jocuri video pot fi folosite în procesul de schimbare organizaţională din perspectiva comunicării organizaţionale, cu obiectivul de a eficientiza schimbarea şi de a integra în contextul orga­ni ...
Tudor MIC
doaj  

The Trend towards “Smart Cities”

International Journal of Automation and Smart Technology, 2014
Looking back over the past century, the steady pace of development in many of the world’s cities has resulted in a situation where a high percentage of these cities are now faced with the problem of aging, decrepit urban infrastructure; a considerable ...
Chien-Chu Chen
doaj   +1 more source

Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases

, 2009
Background - There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains ...
Gurdyal S Besra, Alistair K. Brown, Bhatt, Apoorva; id_orcid, Apoorva Bhatt, Bhatt Apoorva, Besra, Gurdyal; id_orcid, Klaus Fütterer, Besra, Gurdyal, Futterer, Klaus, Taylor, Rebecca, Rebecca C Taylor, Fütterer Klaus, Besra Gurdyal S., Bhatt, Apoorva, Alistair K Brown, Taylor Rebecca C., Rebecca C. Taylor, Gurdyal S. Besra, Brown Alistair K., Brown, Alistair   +19 more
core   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Blood supply of the human carotid body

Scientific Reports
Glomic arteries (GAs) supply the carotid body (CB), a chemosensory organ at the carotid bifurcation. Accurate knowledge of GA anatomy is essential for CB surgery and understanding the impact of carotid artery atherosclerosis on breathing and blood ...
Atieh Seyedian Moghaddam, Stefan H. Geyer, Berna Dogan, Paata Pruidze, Jeremias T. Weninger, Karoline M. Schwendt, Wolfgang J. Weninger   +6 more
doaj   +1 more source