Results 61 to 70 of about 210,832 (261)

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Heavy Metal Tolerance Among Free-living Fungi Isolated from Soil Receiving Long Term Application of Wastewater

Journal of Pure and Applied Microbiology, 2020
In this study fungal profiles of agricultural field soil irrigated with industrial wastewater and sewage containing varying concentrations of heavy metals (Chromium, Nickel, Cobalt, Copper and Cadmium) have been investigated.
Mohd. Imran, Iqbal Ahmad, Tharcisse Barasubiye, Hussein H. Abulreesh, Samreen, Mohammad Khalil Monjed, Khaled Elbanna   +6 more
doaj   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Multiclass Classification Procedure for Detecting Attacks on MQTT-IoT Protocol

Complexity, 2019
The large number of sensors and actuators that make up the Internet of Things obliges these systems to use diverse technologies and protocols. This means that IoT networks are more heterogeneous than traditional networks.
Hector Alaiz-Moreton, Jose Aveleira-Mata, Jorge Ondicol-Garcia, Angel Luis Muñoz-Castañeda, Isaías García, Carmen Benavides   +5 more
doaj   +1 more source

Assessment of Masonry Wall Deformation through Vertical Displacement Gradients Using COSMO-SkyMed SAR Interferometry: The Case Study of Archaeological Park of Pompeii [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
A multi-level, multi-scale monitoring approach, leveraging WebGIS, Internet of Things (IoT), and Digital Twins, has been implemented at the Archaeological Park of Pompeii (PAP) to support proactive maintenance process for the preservation of the site ...
F. Aufiero, V. Calvanese, A. Di Benedetto, M. Fiani, L. Petti, A. Zambrano, G. Zuchtriegel   +6 more
doaj   +1 more source

Propolis Affects Pseudomonas aeruginosa Growth, Biofilm Formation, eDNA Release and Phenazine Production: Potential Involvement of Polyphenols

Microorganisms, 2020
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen responsible for a wide range of clinical conditions, from mild infections to life-threatening nosocomial biofilm-associated diseases, which are particularly severe in susceptible ...
Aida Meto, Bruna Colombari, Agron Meto, Giorgia Boaretto, Diego Pinetti, Lucia Marchetti, Stefania Benvenuti, Federica Pellati, Elisabetta Blasi   +8 more
doaj   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Annexin A2 and lamin B join membrane recycling compartments for the assembly of biomolecular condensates operating in mitotic partitioning

Frontiers in Cell and Developmental Biology
Localization of the actin-, lipid- and mRNA-binding protein Annexin A2 (AnxA2) in dividing cells revealed its presence in large spherical structures which are confined to the cell periphery and frequently co-align with astral microtubules.
Ann Kari Grindheim, Ann Kari Grindheim, Hege Dale, Josef Novák, Sudarshan Shantinath Patil, Anni Vedeler, Jaakko Saraste, Jaakko Saraste   +7 more
doaj   +1 more source